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The objective of this study was to assess the effects of opioid blockade on OLZ-treated patients\u2019 metabolic status. Patients with schizophrenia or schizoaffective disorder ( n=30) on a stable dose of OLZ were randomized in a double-blind fashion to receive an opioid receptor antagonist, naltrexone (NTX), ( n=14) or placebo ( n=16). The primary outcome measure was the change in body mass index (BMI) at 12 weeks. Secondary measures included body fat and fat-free mass, along with homeostasis model assessment-estimated insulin resistance (HOMA-IR), plasma lipids and liver function tests (LFTs). There was no significant change in BMI between the treatment arms. However, in comparison to the OLZ + placebo combination, the OLZ + NTX group displayed a significant decrease in the fat and increase in fat-free mass along with a trend towards improvement in HOMA-IR values. There were no significant differences in plasma lipids and LFTs. These findings suggest that addition of NTX to OLZ may attenuate OLZ-induced body fat mass gain. A larger study of longer duration will be needed to confirm these results.<\/jats:p>","DOI":"10.1177\/0269881113509904","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T22:40:16Z","timestamp":1384209616000},"page":"395-400","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["The effect of naltrexone on body fat mass in olanzapine-treated schizophrenic or schizoaffective patients: A randomized double-blind placebo-controlled pilot study"],"prefix":"10.1177","volume":"28","author":[{"given":"Tracey H","family":"Taveira","sequence":"first","affiliation":[{"name":"Providence VA Medical Center, Providence, RI, USA"},{"name":"Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chih","family":"Wu","sequence":"additional","affiliation":[{"name":"Providence VA Medical Center, Providence, RI, USA"},{"name":"Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Tschibelu","sequence":"additional","affiliation":[{"name":"McLean Hospital, Clinical Psychopathology Laboratory, Belmont, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Borsook","sequence":"additional","affiliation":[{"name":"McLean Hospital, Clinical Psychopathology Laboratory, Belmont, MA, USA"},{"name":"Harvard Medical School, Cambridge, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald C","family":"Simonson","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Cambridge, MA, USA"},{"name":"Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rinah","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"McLean Hospital, Clinical Psychopathology Laboratory, Belmont, MA, USA"},{"name":"Harvard Medical School, Cambridge, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel D","family":"Langleben","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Swift","sequence":"additional","affiliation":[{"name":"Providence VA Medical Center, Providence, RI, USA"},{"name":"Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Elman","sequence":"additional","affiliation":[{"name":"Providence VA Medical Center, Providence, RI, USA"},{"name":"Harvard Medical School, Cambridge, MA, USA"},{"name":"Cambridge Health Alliance, Somerville, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,11,11]]},"reference":[{"key":"bibr1-0269881113509904","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.11.1686"},{"key":"bibr2-0269881113509904","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.176158"},{"key":"bibr3-0269881113509904","doi-asserted-by":"publisher","DOI":"10.1006\/appe.1999.0284"},{"key":"bibr4-0269881113509904","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-18034"},{"key":"bibr5-0269881113509904","doi-asserted-by":"publisher","DOI":"10.2174\/138161211795656774"},{"key":"bibr6-0269881113509904","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.02.044"},{"key":"bibr7-0269881113509904","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-012-0230-7"},{"key":"bibr8-0269881113509904","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/35.1.91"},{"key":"bibr9-0269881113509904","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.4088\/JCP.v65n0101","volume":"65","author":"Casey DE","year":"2004","journal-title":"J Clin Psychiatry"},{"key":"bibr10-0269881113509904","unstructured":"David SP, Lancaster T, Stead LF, (2013) Opioid antagonists for smoking cessation. 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