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There have been two trials on eicosapentanoic acid (EPA) and docosahexanoic acid (DHA) in the treatment of borderline personality disorder (BPD). The present 12-week controlled trial aimed to assess the efficacy of the association of EPA and DHA with valproic acid, compared to single valproic acid, in 43 consecutive BPD outpatients. Participants were evaluated at baseline and after 12 weeks with: Clinical Global Impression \u2013 Severity (CGI-S), Hamilton Scales for depression and anxiety (HAM-D, HAM-A), Social and Occupational Functioning Assessment Scale (SOFAS), borderline personality disorder severity index (BPDSI), Barratt Impulsiveness Scale \u2013 version 11 (BIS-11), Modified Overt Aggression Scale (MOAS), Self-Harm Inventory (SHI) and Dosage Record Treatment Emergent Symptom Scale (DOTES).<\/jats:p>","DOI":"10.1177\/0269881113510072","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T21:08:49Z","timestamp":1383772129000},"page":"125-132","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":50,"title":["Efficacy of omega-3 fatty acids in the treatment of borderline personality disorder: A study of the association with valproic acid"],"prefix":"10.1177","volume":"28","author":[{"given":"Silvio","family":"Bellino","sequence":"first","affiliation":[{"name":"Department of Neuroscience, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bozzatello","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Rocca","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Bogetto","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,11,5]]},"reference":[{"key":"bibr1-0269881113510072","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2000","edition":"4"},{"key":"bibr2-0269881113510072","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.192"},{"key":"bibr3-0269881113510072","doi-asserted-by":"publisher","DOI":"10.1521\/pedi.17.1.45.24053"},{"key":"bibr4-0269881113510072","doi-asserted-by":"publisher","DOI":"10.1097\/01.yic.0000224790.98534.11"},{"key":"bibr5-0269881113510072","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1965.16.2.547"},{"key":"bibr6-0269881113510072","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2007.01.004"},{"key":"bibr7-0269881113510072","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(03)00168-9"},{"key":"bibr8-0269881113510072","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n1219b"},{"key":"bibr9-0269881113510072","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.11.2088"},{"key":"bibr10-0269881113510072","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2007.06.029"},{"key":"bibr11-0269881113510072","volume-title":"Structured Clinical Interview for DSM-IV Axis II Disorders (SCID-II)","author":"First MB","year":"1997"},{"key":"bibr12-0269881113510072","volume-title":"Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I)","author":"First MB","year":"1997"},{"key":"bibr13-0269881113510072","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.1051"},{"key":"bibr14-0269881113510072","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.188.1.46"},{"key":"bibr15-0269881113510072","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0511"},{"key":"bibr16-0269881113510072","doi-asserted-by":"publisher","DOI":"10.1080\/09540260600582009"},{"key":"bibr17-0269881113510072","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.105.019562"},{"key":"bibr18-0269881113510072","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.149.9.1148"},{"key":"bibr19-0269881113510072","first-page":"218","volume-title":"Early clinical drug evaluation (ECDEU) Assessment Manual for Psychopharmacology. 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