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This paper reports on the treatment of a patient with IH who was treated with a 96-hour continuous low dose (4 mg\/day) infusion of a benzodiazepine antagonist, flumazenil, followed by a slow-release flumazenil implant. The use of flumazenil mitigated the patient\u2019s IH symptoms including excessive daytime sleepiness, sleep drunkenness and self-reported cognitive problems. The case both provides a possible treatment and system for short (subcutaneous (SC) administration) and longer term (implant) flumazenil delivery. Current data supports the need for further research into the use of flumazenil for the treatment of IH and to develop long term flumazenil delivery systems.<\/jats:p>","DOI":"10.1177\/0269881114523865","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T21:31:10Z","timestamp":1392845470000},"page":"703-706","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Use of subcutaneous flumazenil preparations for the treatment of idiopathic hypersomnia: A case report"],"prefix":"10.1177","volume":"28","author":[{"given":"Erin","family":"Kelty","sequence":"first","affiliation":[{"name":"Fresh Start Recovery Programme, Subiaco, WA, Australia"},{"name":"School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlad","family":"Martyn","sequence":"additional","affiliation":[{"name":"Fresh Start Recovery Programme, Subiaco, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"O\u2019Neil","sequence":"additional","affiliation":[{"name":"Fresh Start Recovery Programme, Subiaco, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Hulse","sequence":"additional","affiliation":[{"name":"School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,2,19]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.8.1423"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70274-7"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-198912000-00005"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/1355621021000005973"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1973.tb00801.x"},{"key":"e_1_3_3_7_1","first-page":"1","article-title":"The role of flumazenil in the treatment of benzodiazepine dependence: Physiological and psychological profile","volume":"22","author":"Hood S","year":"2009","unstructured":"Hood S, O\u2019Neil G, Hulse G (2009) The role of flumazenil in the treatment of benzodiazepine dependence: Physiological and psychological profile. 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