{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:22:28Z","timestamp":1784892148418,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>\n                    A wealth of evidence indicates that the activation of 5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    and 5-HT\n                    <jats:sub>2A<\/jats:sub>\n                    receptors in the dorsal periaqueductal grey matter (dPAG) inhibits escape, a panic-related defensive behaviour. Results that were previously obtained with the elevated T-maze test of anxiety\/panic suggest that 5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    and \u03bc-opioid receptors in this midbrain area work together to regulate this response. To investigate the generality of this finding, we assessed whether the same cooperative mechanism is engaged when escape is evoked by a different aversive stimulus electrical stimulation of the dPAG. Administration of the \u03bc-receptor blocker CTOP into the dPAG did not change the escape threshold, but microinjection of the \u03bc-receptor agonist DAMGO (0.3 and 0.5 nmol) or the 5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    receptor agonist 8-OHDPAT (1.6 nmol) increased this index, indicating a panicolytic-like effect. Pretreatment with CTOP antagonised the anti-escape effect of 8-OHDPAT. Additionally, combined administration of subeffective doses of DAMGO and 8-OHDPAT increased the escape threshold, indicating drug synergism. Therefore, regardless of the aversive nature of the stimulus, \u03bc-opioid and 5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    receptors cooperatively act to regulate escape behaviour. A better comprehension of this mechanism might allow for new therapeutic strategies for panic disorder.\n                  <\/jats:p>","DOI":"10.1177\/0269881114554274","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T00:26:01Z","timestamp":1413332761000},"page":"1155-1160","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Interaction between \u03bc-opioid and 5-HT\n                    <sub>1A<\/sub>\n                    receptors in the regulation of panic-related defensive responses in the rat dorsal periaqueductal grey"],"prefix":"10.1177","volume":"28","author":[{"given":"Marcel P","family":"Rangel","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Maring\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"H\u00e9lio","family":"Zangrossi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo (USP), Ribeir\u00e3o Preto, Brazil"},{"name":"NAP-NuPNE \u2013 Neurobiology of Emotion Research Centre, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila M","family":"Roncon","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo (USP), Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico G","family":"Graeff","sequence":"additional","affiliation":[{"name":"INeC \u2013 Institute of Behavioral Neuroscience, Ribeir\u00e3o Preto, Brazil"},{"name":"NAP-NuPNE \u2013 Neurobiology of Emotion Research Centre, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth A","family":"Audi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Maring\u00e1, Brazil"},{"name":"INeC \u2013 Institute of Behavioral Neuroscience, Ribeir\u00e3o Preto, 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