{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:29:13Z","timestamp":1777858153613,"version":"3.51.4"},"reference-count":61,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T00:00:00Z","timestamp":1421625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>\n                    Panic attacks, a major feature of panic disorder, can be modelled in rats by exposing animals to stimuli that induce escape reactions, such as the elevated T-maze or the activation of the dorsolateral periaqueductal grey. Since the cannabinoid CB\n                    <jats:sub>1<\/jats:sub>\n                    receptor modulates various types of aversive responses, this study tested the hypothesis that enhancement of endocannabinoid signalling in the dorsolateral periaqueductal grey inhibits panic-like reactions in rats. Local injection of the CB\n                    <jats:sub>1<\/jats:sub>\n                    agonist, arachidonoyl 2-Chloroethylamide (0.005\u20130.5 pmol), attenuated the escape response from the open arm of the elevated T-maze, a panicolytic effect. The anandamide hydrolysis inhibitor, URB597 (0.3\u20133 nmol), did not induce consistent results. In the test of dorsolateral periaqueductal grey stimulation with d,l-homocysteic acid, arachidonoyl 2-Chloroethylamide, at the lowest dose, attenuated the escape reaction. The highest dose of URB597 also inhibited this response, contrary to the result obtained in the elevated T-maze. This effect was reversed by the CB\n                    <jats:sub>1<\/jats:sub>\n                    antagonist, AM251 (100 pmol). The present results confirm the anti-aversive property of direct CB\n                    <jats:sub>1<\/jats:sub>\n                    receptor activation in the dorsolateral periaqueductal grey. The effect of the anandamide hydrolysis inhibitor, however, could be detected only in a model employing direct stimulation of this structure. Altogether, these results suggest that anandamide signalling is recruited only under certain types of aversive stimuli.\n                  <\/jats:p>","DOI":"10.1177\/0269881114566259","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T23:07:41Z","timestamp":1421708861000},"page":"335-343","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Role of endocannabinoid signalling in the dorsolateral periaqueductal grey in the modulation of distinct panic-like responses"],"prefix":"10.1177","volume":"29","author":[{"given":"Luara A","family":"Batista","sequence":"first","affiliation":[{"name":"Graduate School in Neuroscience, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana R","family":"Bastos","sequence":"additional","affiliation":[{"name":"Graduate School in Neuroscience, 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