{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:29:06Z","timestamp":1777858146549,"version":"3.51.4"},"reference-count":58,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:00:00Z","timestamp":1438905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>\n                    Biochemical, pharmacological and genetic evidence suggests the involvement of the endocannabinoid system in alcohol dependence. The aim of the present study was to evaluate the state of CB\n                    <jats:sub>1<\/jats:sub>\n                    receptors in post-mortem caudate nucleus, hippocampus and cerebellum of alcoholic subjects.\n                  <\/jats:p>\n                  <jats:p>\n                    CB\n                    <jats:sub>1<\/jats:sub>\n                    protein levels were measured by Western blot, CB\n                    <jats:sub>1<\/jats:sub>\n                    receptor density and affinity by [\n                    <jats:sup>3<\/jats:sup>\n                    H]WIN55,212-2 saturation assays and CB\n                    <jats:sub>1<\/jats:sub>\n                    functionality by [\n                    <jats:sup>35<\/jats:sup>\n                    S]GTP\u03b3S binding assays. Experiments were performed in samples from 24 subjects classified as non-suicidal alcoholics ( n = 6), suicidal alcoholics ( n = 6), non-alcoholic suicide victims ( n = 6) and control subjects ( n = 6).\n                  <\/jats:p>\n                  <jats:p>\n                    Alcoholic subjects presented hyperfunctional CB\n                    <jats:sub>1<\/jats:sub>\n                    receptors in the caudate nucleus resulting in a higher maximal effect in both alcoholic groups compared to the non-alcoholic groups ( p &lt; 0.001). Conversely, in the cerebellum the non-suicidal alcoholic subjects showed hypofunctional receptors with lower maximal effect and potency ( p &lt; 0.001). No changes were found in the CB\n                    <jats:sub>1<\/jats:sub>\n                    protein expression in either region. In the hippocampus of alcoholic subjects, no changes were observed either in the functionality, density or protein levels.\n                  <\/jats:p>\n                  <jats:p>Our data support an association between endocannabinoid system activity and alcoholism. The modifications reported here could be either a consequence of high lifetime ethanol consumption or a vulnerability factor to develop alcohol addiction.<\/jats:p>","DOI":"10.1177\/0269881115599388","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T21:39:47Z","timestamp":1438983587000},"page":"1137-1145","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Altered CB\n                    <sub>1<\/sub>\n                    receptor coupling to G-proteins in the post-mortem caudate nucleus and cerebellum of alcoholic subjects"],"prefix":"10.1177","volume":"29","author":[{"given":"Amaia M","family":"Erdozain","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of the Basque Country UPV\/EHU, Bizkaia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Madrid, Spain"},{"name":"Current address: Neuroscience Paris Seine, CNRS UMR 8246, INSERM U1130, Universit\u00e9 Pierre et Marie Curie, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Rubio","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Javier","family":"Meana","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of the Basque Country UPV\/EHU, Bizkaia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Madrid, Spain"},{"name":"Biocruces Health Research Institute, Bizkaia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Fern\u00e1ndez-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain"},{"name":"Instituto Ram\u00f3n y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis F","family":"Callado","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of the Basque Country UPV\/EHU, Bizkaia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Madrid, Spain"},{"name":"Biocruces Health Research Institute, Bizkaia, 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