{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T03:31:22Z","timestamp":1783913482527,"version":"3.55.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Olanzapine\u2019s efficacy in schizophrenia is attributed to antagonism of dopamine and serotonin receptors. Olanzapine is also a potent histamine-H1 antagonist that results in weight gain and somnolence. Betahistine is a centrally acting histamine-H1 agonist, and therefore may reduce olanzapine\u2019s effect on histamine receptors in the brain. Olanzapine\u2019s high affinity for the histamine-H1 receptor warrants the use of high doses of betahistine. Forty-eight healthy women were recruited and randomized to receive either betahistine 144 mg\/day or matching placebo for 4 weeks. Due to the high dose of betahistine, olanzapine was started only on the second week and titrated up to 10 mg\/day, and co-administration continued for an additional 2 weeks. Only nominal differences in adverse events were noted between the treatment groups. Betahistine caused a 37% reduction in mean weight gain (1.24 kg in the betahistine arm vs. 1.93 kg in the placebo arm; p=.049) and 60% reduction in the mean increase in daytime Epworth sleepiness scores (1.82 units in the betahistine group vs. 3.57 units in the placebo group; p=.042). The present study suggests that betahistine\u2013olanzapine co-administration, in healthy female subjects, yields an acceptable safety profile with mitigation of weight gain and somnolence. This should be further tested in a patient cohort.<\/jats:p>","DOI":"10.1177\/0269881115626349","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T21:03:13Z","timestamp":1454446993000},"page":"237-241","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Betahistine decreases olanzapine-induced weight gain and somnolence in humans"],"prefix":"10.1177","volume":"30","author":[{"given":"Nir","family":"Barak","sequence":"first","affiliation":[{"name":"Obesity Clinic, Leumit Health Fund, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaffa","family":"Beck","sequence":"additional","affiliation":[{"name":"Private Practice, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph H","family":"Albeck","sequence":"additional","affiliation":[{"name":"Private Practice, Belmont, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,2,2]]},"reference":[{"key":"bibr1-0269881115626349","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0812"},{"key":"bibr2-0269881115626349","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200822070-00002"},{"key":"bibr3-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(85)90115-3"},{"key":"bibr4-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1177\/070674370605100310"},{"key":"bibr5-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.17.5.795"},{"key":"bibr6-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.135"},{"key":"bibr7-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1177\/0269881112449396"},{"key":"bibr8-0269881115626349","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0217"},{"key":"bibr9-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.9.1744"},{"key":"bibr10-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.5.954"},{"key":"bibr11-0269881115626349","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200629110-00004"},{"key":"bibr12-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611417104"},{"key":"bibr13-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60733-3"},{"key":"bibr14-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1647-2"},{"key":"bibr15-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.08.005"},{"key":"bibr16-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.08.006"},{"key":"bibr17-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104160"},{"key":"bibr18-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.06.010"},{"key":"bibr19-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.02.001"},{"key":"bibr20-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-200503000-00007"},{"key":"bibr21-0269881115626349","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.07r03982"},{"key":"bibr22-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.12.009"},{"key":"bibr23-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1080\/00016480701724912"},{"key":"bibr24-0269881115626349","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v60n0602"},{"key":"bibr25-0269881115626349","doi-asserted-by":"publisher","DOI":"10.1097\/mjt.0000000000000061"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881115626349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0269881115626349","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881115626349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:06:36Z","timestamp":1777507596000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0269881115626349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,2]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1177\/0269881115626349"],"URL":"https:\/\/doi.org\/10.1177\/0269881115626349","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,2]]}}}