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Six independent, blind judges analysed mentation reports acquired during structured interviews performed shortly after the functional magnetic resonance imaging (fMRI) scans (approximately 2.5 h post-administration). Within each report, specific linguistic references to mental spaces for the past, present and future were identified. Results revealed significantly fewer mental spaces for the past under LSD and this effect correlated with the general intensity of the drug\u2019s subjective effects. No differences in the number of mental spaces for the present or future were observed. Consistent with the previously proposed role of the default-mode network (DMN) in autobiographical memory recollection and ruminative thought, decreased resting-state functional connectivity (RSFC) within the DMN correlated with decreased mental time travel to the past. These results are discussed in relation to potential therapeutic applications of LSD and related psychedelics, e.g. in the treatment of depression, for which excessive reflection on one\u2019s past, likely mediated by DMN functioning, is symptomatic.<\/jats:p>","DOI":"10.1177\/0269881116628430","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T06:51:35Z","timestamp":1458024695000},"page":"344-353","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":85,"title":["Decreased mental time travel to the past correlates with default-mode network disintegration under lysergic acid diethylamide"],"prefix":"10.1177","volume":"30","author":[{"given":"Jana","family":"Speth","sequence":"first","affiliation":[{"name":"Department of Psychology, School of Social Sciences, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Speth","sequence":"additional","affiliation":[{"name":"Department of Psychology, School of Social Sciences, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mendel","family":"Kaelen","sequence":"additional","affiliation":[{"name":"Centre for Neuropsychopharmacology, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid M","family":"Schloerscheidt","sequence":"additional","affiliation":[{"name":"Department of Psychology, School of Social Sciences, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Feilding","sequence":"additional","affiliation":[{"name":"Beckley Foundation, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Nutt","sequence":"additional","affiliation":[{"name":"Centre for Neuropsychopharmacology, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin L","family":"Carhart-Harris","sequence":"additional","affiliation":[{"name":"Centre for Neuropsychopharmacology, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,3,15]]},"reference":[{"key":"bibr1-0269881116628430","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20405"},{"key":"bibr2-0269881116628430","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00830.2009"},{"key":"bibr3-0269881116628430","doi-asserted-by":"publisher","DOI":"10.1177\/2045125314527985"},{"key":"bibr4-0269881116628430","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsq080"},{"key":"bibr5-0269881116628430","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114565144"},{"key":"bibr6-0269881116628430","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112029108"},{"key":"bibr7-0269881116628430","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"bibr8-0269881116628430","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3475"},{"key":"bibr9-0269881116628430","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.04.001"},{"key":"bibr10-0269881116628430","doi-asserted-by":"publisher","DOI":"10.1080\/15294145.2007.10773557"},{"key":"bibr11-0269881116628430","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2014.00255"},{"key":"bibr12-0269881116628430","unstructured":"Carhart-Harris RL (2015) The neural correlates of the LSD state as determined by multimodal functional brain imaging. 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