{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:47:35Z","timestamp":1790660855553,"version":"4.1.0"},"reference-count":98,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T00:00:00Z","timestamp":1468108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>\n                    Functional interactions between cannabinoid and alpha-2 adrenergic systems in cognitive control in the medial prefrontal cortex (mPFC) seem possible. The present study evaluated the possible role of alpha-2 adrenoceptors of the prefrontal cortex on effect of arachidonylcyclopropylamide (ACPA), a cannabinoid CB\n                    <jats:sub>1<\/jats:sub>\n                    receptor (CB\n                    <jats:sub>1<\/jats:sub>\n                    R) agonist, in adult male Wistar rats. The animals were bilaterally implanted with chronic cannulae in the mPFC, trained in a step-through task, and tested 24 h after training to measure step-through latency. Results indicate that pre-training microinjection of ACPA (0.05 and 0.5 \u03bcg\/rat) and clonidine (alpha-2 adrenoceptor agonist; 1 and 2 \u03bcg\/rat) reduce memory acquisition. Pre-training subthreshold dose of clonidine (0.5 \u00b5g\/rat) restored memory-impairing effect of ACPA (0.05 and 0.5 \u00b5g\/rat). On the other hand, pre-training administration of the alpha-2 adrenoceptor antagonist yohimbine in all doses used (0.5, 1, and 2 \u03bcg\/rat) did not affect memory acquisition by itself, while a subthreshold dose of yohimbine (2 \u00b5g\/rat) potentiated memory impairment induced by ACPA (0.005 \u00b5g\/rat). Finally, a subthreshold dose of SKF96365 (a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel blocker) blocked clonidine and yohimbine effect of memory responses induced by ACPA. In conclusion, these data indicate that mPFC alpha-2 adrenoceptors play an important role in ACPA-induced amnesia and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels have a critical role this phenomenon.\n                  <\/jats:p>","DOI":"10.1177\/0269881116652585","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T22:24:27Z","timestamp":1466202267000},"page":"945-954","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Involvement of medial prefrontal cortex alpha-2 adrenoceptors on memory acquisition deficit induced by arachidonylcyclopropylamide, a cannabinoid CB\n                    <sub>1<\/sub>\n                    receptor agonist, in rats; possible involvement of Ca\n                    <sup>2+<\/sup>\n                    channels"],"prefix":"10.1177","volume":"30","author":[{"given":"Afsaneh","family":"Beiranvand","sequence":"first","affiliation":[{"name":"Institute for Cognitive Science Studies (ICSS), Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Nasehi","sequence":"additional","affiliation":[{"name":"Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad-Reza","family":"Zarrindast","sequence":"additional","affiliation":[{"name":"Institute for Cognitive Science Studies (ICSS), Tehran, Iran"},{"name":"Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran"},{"name":"Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran"},{"name":"Medical Genomics Research Center, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrnoush","family":"Moghaddasi","sequence":"additional","affiliation":[{"name":"Razi Herbal Medicines Research Center, Department of Physiology, Lorestan University of Medical Sciences, Khorramabad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,10]]},"reference":[{"key":"bibr1-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81904-2"},{"key":"bibr2-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1996.tb02264.x"},{"key":"bibr3-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.03.017"},{"key":"bibr4-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01493-0"},{"key":"bibr5-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1126\/science.2999977"},{"key":"bibr6-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-11-04287.1988"},{"key":"bibr7-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01591-9"},{"key":"bibr8-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.13.7041"},{"key":"bibr9-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0254"},{"key":"bibr10-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0442-05.2005"},{"key":"bibr11-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69031131.x"},{"key":"bibr12-0269881116652585","first-page":"81","volume":"39","author":"Cahill L","year":"1996","journal-title":"Proc West Pharmacol Soc"},{"key":"bibr13-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91034-P"},{"key":"bibr14-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.01.008"},{"key":"bibr15-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.07054.x"},{"key":"bibr16-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.09.020"},{"key":"bibr17-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12690"},{"key":"bibr18-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.09.005"},{"key":"bibr19-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(02)00292-7"},{"key":"bibr20-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.12.007"},{"key":"bibr21-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(92)90050-H"},{"key":"bibr22-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90666-1"},{"key":"bibr23-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/501726"},{"key":"bibr24-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90106-6"},{"key":"bibr25-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2650-05.2005"},{"key":"bibr26-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02544.x"},{"key":"bibr27-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14.10.1432"},{"key":"bibr28-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.05.009"},{"key":"bibr29-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01490.x"},{"key":"bibr30-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.12.010"},{"key":"bibr31-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj133"},{"key":"bibr32-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00351.2004"},{"key":"bibr33-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-19-08771.2002"},{"key":"bibr34-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1126\/science.8389057"},{"key":"bibr35-0269881116652585","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0022-3565(25)13092-9","volume":"277","author":"Gifford AN","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr36-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00428-9"},{"key":"bibr37-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-1047(86)90927-1"},{"key":"bibr38-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1038\/45154"},{"key":"bibr39-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.1998.3875"},{"key":"bibr40-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.26.1.1"},{"key":"bibr41-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.08.018"},{"key":"bibr42-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1124\/pr.54.2.161"},{"key":"bibr43-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00681.x"},{"key":"bibr44-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15639.x"},{"key":"bibr45-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.03.046"},{"key":"bibr46-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e32834aff1f"},{"key":"bibr47-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00805.x"},{"key":"bibr48-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-1772-3"},{"key":"bibr49-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.10.006"},{"key":"bibr50-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301603"},{"key":"bibr51-0269881116652585","first-page":"739","volume":"59","author":"Jin X","year":"2007","journal-title":"Sheng Li Xue Bao"},{"key":"bibr52-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.02.049"},{"key":"bibr53-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.07.083"},{"key":"bibr54-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)02210-6"},{"key":"bibr55-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000709"},{"key":"bibr56-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.014886"},{"key":"bibr57-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.867bj.x"},{"key":"bibr58-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-4-12"},{"key":"bibr59-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(99)00070-6"},{"key":"bibr60-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91049-8"},{"key":"bibr61-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1007\/BF02246292"},{"key":"bibr62-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(87)90527-2"},{"key":"bibr63-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.27.070203.144157"},{"key":"bibr64-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(93)90092-5"},{"key":"bibr65-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300700"},{"key":"bibr66-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1038\/nature00839"},{"key":"bibr67-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.01.002"},{"key":"bibr68-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-16-06795.1999"},{"key":"bibr69-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.11.003"},{"key":"bibr70-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1177\/0269881107077220"},{"key":"bibr71-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04759.x"},{"key":"bibr72-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-23-07768.1996"},{"key":"bibr73-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1007\/s002109900147"},{"key":"bibr74-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2009.05.005"},{"key":"bibr75-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0650-6"},{"key":"bibr76-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.09.110"},{"key":"bibr77-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.11.009"},{"key":"bibr78-0269881116652585","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2004"},{"key":"bibr79-0269881116652585","first-page":"389","volume":"14","author":"Piri M","year":"2011","journal-title":"Arch Iran Med"},{"key":"bibr80-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.31"},{"key":"bibr81-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0508-y"},{"key":"bibr82-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.04.006"},{"key":"bibr83-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.06.003"},{"key":"bibr84-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-26573-2_15"},{"key":"bibr85-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3038-04.2005"},{"key":"bibr86-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01805-8"},{"key":"bibr87-0269881116652585","doi-asserted-by":"publisher","DOI":"10.2174\/1874473710801010081"},{"key":"bibr88-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-2-34"},{"key":"bibr89-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5491-03.2004"},{"key":"bibr90-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00597-6"},{"key":"bibr91-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1095"},{"key":"bibr92-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1007\/BF00169393"},{"key":"bibr93-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.04.025"},{"key":"bibr94-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2015.03.018"},{"key":"bibr95-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00436-3"},{"key":"bibr96-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.actpsy.2007.10.004"},{"key":"bibr97-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.015"},{"key":"bibr98-0269881116652585","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2012.12.001"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881116652585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0269881116652585","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881116652585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:06:47Z","timestamp":1777507607000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0269881116652585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,10]]},"references-count":98,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1177\/0269881116652585"],"URL":"https:\/\/doi.org\/10.1177\/0269881116652585","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,10]]}}}