{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:27:35Z","timestamp":1777858055924,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T00:00:00Z","timestamp":1469664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Synthetic cannabinoids (SC) use has had a dramatic increase in recent years, but data regarding their adverse effects on mental health is limited. In this study, we compared clinical presentations of SC users with cannabis users in a psychiatric inpatient setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Digital charts of all patients who were admitted to a dual diagnosis psychiatric unit in one year were reviewed. Patients who had any current substance use disorder were categorized in four groups: (1) SC use and cannabis use (SC+MJ+), (2) SC use without cannabis use (SC+MJ-), (3) cannabis use without SC use (SC-MJ+), and (4) No SC or cannabis use (SC-MJ-).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 594 charts were included. SC+MJ- patients had significantly more psychotic symptoms (OR: 4.44, 95% CI: 1.98\u20139.94), followed by SC+MJ+ (OR: 3.61, 95% CI: 1.87\u20136.97) and SC-MJ+ (OR: 1.87, 95%CI: 1.33\u20132.64) patients. The SC+MJ- group also had more agitation and aggression was most prominent in SC+MJ+ subjects. Multivariate analyses showed that the psychiatric associations of SC and cannabis use remained significant even after controlling for potential confounds such as other substance use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The prominent psychiatric features of SC users as compared to cannabis users in an inpatient setting are psychotic presentations and agitation, which have important treatment implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269881116658990","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T20:33:19Z","timestamp":1469565199000},"page":"1321-1330","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":69,"title":["Psychiatric comorbidity associated with synthetic cannabinoid use compared to cannabis"],"prefix":"10.1177","volume":"30","author":[{"given":"Anahita","family":"Bassir Nia","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Mount Sinai Beth Israel Medical Center, Icahn School of Medicine at Mount Sinai at New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Medrano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Mount Sinai Beth Israel Medical Center, Icahn School of Medicine at Mount Sinai at New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Perkel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Mount Sinai Beth Israel Medical Center, Icahn School of Medicine at Mount Sinai at New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Galynker","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Mount Sinai Beth Israel Medical Center, Icahn School of Medicine at Mount Sinai at New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin L","family":"Hurd","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai at New York, Mount Sinai Behavioral Health System, New York, NY, 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