{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:45:02Z","timestamp":1789919102359,"version":"4.0.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Cannabidiol is a non-psychoactive compound that is the second most abundant component of cannabis. It has been shown to have a potential therapeutic value for a wide range of disorders, including anxiety, psychosis, and depression. Recently, it was suggested that cannabidiol might be a potential treatment for heroin craving and relapse. Here we investigated the effects of an acute treatment with cannabidiol on cocaine self-administration and cue-induced cocaine seeking in rats. Rats were trained to press a lever to self-administer cocaine (0.5 mg\/kg\/infusion), first under a fixed interval 20 s (FI-20 s) and then under a progressive ratio (PR) schedule of reinforcement. Cocaine self-administration under a PR schedule of reinforcement was not attenuated by cannabidiol injections (5.0 mg\/kg and 10.0 mg\/kg; i.p.) when tested 30 min and 24 h after treatment. Cannabidiol treatment (5.0 mg\/kg or 10.0 mg\/kg) also did not attenuate cue-induced cocaine seeking in rats after a withdrawal period of 14 days. In contrast, treatment with cannabidiol (10.0 mg\/kg; i.p.) resulted in a statistically significant anxiolytic effect in the elevated plus-maze. Our findings suggest that, under the conditions described here, an acute cannabidiol treatment has a minimal effect on a rat model of cocaine intake and relapse.<\/jats:p>","DOI":"10.1177\/0269881116667706","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T20:48:23Z","timestamp":1473799703000},"page":"96-104","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Effects of an acute cannabidiol treatment on cocaine self-administration and cue-induced cocaine seeking in male rats"],"prefix":"10.1177","volume":"31","author":[{"given":"Ashraf","family":"Mahmud","sequence":"first","affiliation":[{"name":"Department of Psychology, CSBN\/GRNC, Concordia University, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Gallant","sequence":"additional","affiliation":[{"name":"Department of Psychology, CSBN\/GRNC, Concordia 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