{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:12:21Z","timestamp":1790835141969,"version":"4.1.0"},"reference-count":86,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T00:00:00Z","timestamp":1479513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Unipolar mood disorders, including major depressive disorder and persistent depressive disorder (dysthymia), confer high rates of disability and mortality and a very high socioeconomic burden. Current treatment is suboptimal in most cases and there is little of note in the pharmaceutical development pipeline. The psychedelic drugs, including lysergic acid diethylamide and psilocybin, were used extensively in the treatment of mood disorders, and other psychiatric conditions, before their prohibition in the late 1960s. They are relatively safe when used in medically controlled environments, with no reported risk of dependence. Here, we present a systematic review of published clinical treatment studies using psychedelics in patients with broadly defined UMD, and consider their place in psychiatry. Whilst all of the included studies have methodological shortcomings, of 423 individuals in 19 studies, 335 (79.2%) showed clinician-judged improvement after treatment with psychedelics. A recently completed pilot study in the UK favours the use of psilocybin with psychological support in treatment resistant depressive disorder. The evidence overall strongly suggests that psychedelics should be re-examined in modern clinical trials for their use in unipolar mood disorders and other non-psychotic mental health conditions.<\/jats:p>","DOI":"10.1177\/0269881116679368","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T23:30:20Z","timestamp":1479425420000},"page":"1220-1229","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":151,"title":["Psychedelics in the treatment of unipolar mood disorders: a systematic review"],"prefix":"10.1177","volume":"30","author":[{"given":"James JH","family":"Rucker","sequence":"first","affiliation":[{"name":"The Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, UK"},{"name":"South West London and St George\u2019s Mental Health NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke A","family":"Jelen","sequence":"additional","affiliation":[{"name":"The Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, UK"},{"name":"South London and Maudsley NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Flynn","sequence":"additional","affiliation":[{"name":"King\u2019s College London School of Medicine, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle D","family":"Frowde","sequence":"additional","affiliation":[{"name":"King\u2019s College London School of Medicine, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan H","family":"Young","sequence":"additional","affiliation":[{"name":"The Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London, UK"},{"name":"South London and Maudsley NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,11,19]]},"reference":[{"key":"bibr1-0269881116679368","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01224-X"},{"key":"bibr2-0269881116679368","first-page":"191","volume-title":"The use of LSD in psychotherapy and alcoholism","author":"Baker EFW","year":"1967"},{"key":"bibr3-0269881116679368","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1376"},{"key":"bibr4-0269881116679368","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114565144"},{"key":"bibr5-0269881116679368","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08701-9"},{"key":"bibr6-0269881116679368","volume-title":"Goodman and Gilman\u2019s The Pharmacological Basis of Therapeutics","author":"Brunton L","year":"2011","edition":"12"},{"key":"bibr7-0269881116679368","first-page":"241","volume":"11","author":"Busch AK","year":"1950","journal-title":"Dis Nervous Syst"},{"key":"bibr8-0269881116679368","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq010"},{"key":"bibr9-0269881116679368","doi-asserted-by":"publisher","DOI":"10.3109\/14659890903271624"},{"key":"bibr10-0269881116679368","first-page":"619","volume":"3","author":"Carhart-Harris RL","year":"2016","journal-title":"Lancet"},{"key":"bibr11-0269881116679368","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119598109"},{"key":"bibr12-0269881116679368","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1518377113"},{"key":"bibr13-0269881116679368","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1960.03590090042008"},{"key":"bibr14-0269881116679368","doi-asserted-by":"publisher","DOI":"10.1177\/0269881115581093"},{"key":"bibr15-0269881116679368","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-196001000-00005"},{"key":"bibr16-0269881116679368","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1949.tb04588.x"},{"key":"bibr17-0269881116679368","unstructured":"Denenmark L (2015) The Altering State of Psychedelics Research. 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