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PS procedure did not affect body weight of the offspring. MDSD induced decreases in body weight both in male and female offspring (1 month) that were still present in aged rats. HFSD induced an increase in body weight both in male and female offspring that did not persist in aged rats. In the Porsolt forced swimming test, only young males showed increases in immobility time that were reversed by MDSD. In old female rats (20 months), PS-induced cognitive impairment in both the novel object recognition test (NORT) and in the Morris water maze that was reversed by MDSD, whereas in old males, cognitive impairments and reversion by MDSD was evident only in the Morris water maze. HFSD induced cognitive impairment in both control and PS old rats, but there was no additive effect of PS and HFSD. It is proposed here that the diversity of symptoms following PS could arise from programming effects in early brain development and that these effects could be modified by dietary intake of the dam.<\/jats:p>","DOI":"10.1177\/0269881116686881","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T03:47:13Z","timestamp":1485229633000},"page":"356-364","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of perinatal diet and prenatal stress on the behavioural profile of aged male and female rats"],"prefix":"10.1177","volume":"31","author":[{"given":"Xabier","family":"Bengoetxea","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Paternain","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Food 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