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Depression is a recurrent and disabling psychiatric illness and current evidences support that oxidative stress and neuroinflammation are mechanisms underlying the pathophysiology of this psychiatric condition. Here, we evaluated the effect of 3-((4-chlorophenyl)selanyl)-1-methyl-1H-indole (CMI) in lipopolysaccharide (LPS)-induced depressive-like behaviour, neuroinflammation and oxidative stress in male mice. CMI pre-treatment (20 and 50 mg\/kg, intragastrically) significantly attenuated LPS (0.83 mg\/kg, intraperitoneally)-induced depressive-like behaviour in mice by reducing the immobility time in the tail suspension test (TST) and forced swimming test (FST). CMI pre-treatment ameliorated LPS-induced neuroinflammation by reducing the levels of interleukin (IL)-1\u03b2, IL-4 and IL-6 in the hippocampus and prefrontal cortex, as well as markers of oxidative damage. Additionally, we investigated the toxicological effects of CMI (200 mg\/kg, i.g.) in the liver, kidney and brain through determination of the activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), \u03b4-aminolevulinate dehydratase (\u03b4-ALA-D) and creatinine levels. These biomarkers were not modified, indicating the possible absence of neuro-, hepato- and nephrotoxic effects. Our results suggest that CMI could be a therapeutic approach for the treatment of depression and other neuropsychiatric disorders associated with inflammation and oxidative stress.<\/jats:p>","DOI":"10.1177\/0269881117711713","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T10:00:28Z","timestamp":1498730428000},"page":"1263-1273","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":72,"title":["Antidepressant-like effect of a new selenium-containing compound is accompanied by a reduction of neuroinflammation and oxidative stress in lipopolysaccharide-challenged mice"],"prefix":"10.1177","volume":"31","author":[{"given":"Angela M","family":"Casaril","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biotecnologia (PPGB), Grupo de Pesquisa em Neurobiotecnologia, Biotecnologia\/Centro de Desenvolvimento Tecnol\u00f3gico, Universidade Federal de 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana K","family":"Seixas","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biotecnologia (PPGB), Grupo de Pesquisa em Oncologia Celular e Molecular, Laborat\u00f3rio de Gen\u00f4mica Funcional, Biotecnologia\/Centro de Desenvolvimento Tecnol\u00f3gico, Universidade Federal de Pelotas, Pelotas, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Collares","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biotecnologia (PPGB), Grupo de Pesquisa em Oncologia Celular e Molecular, Laborat\u00f3rio de Gen\u00f4mica Funcional, Biotecnologia\/Centro de Desenvolvimento Tecnol\u00f3gico, Universidade Federal de Pelotas, Pelotas, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina W","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Departamento de 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