{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:28:06Z","timestamp":1777858086128,"version":"3.51.4"},"reference-count":65,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T00:00:00Z","timestamp":1504137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Animal and clinical researches indicate that the opioid system exerts a crucial role in the etiology of mood disorders and is a target for intervention in depression treatment. This study investigated the contribution of the opioid system to the antidepressant-like action of acute or repeated m-trifluoromethyl-diphenyl diselenide administration to Swiss mice. m-Trifluoromethyl-diphenyl diselenide (50 mg\/kg, intragastric) produced an antidepressant-like action in the forced swimming test from 30 min to 24 h after treatment. This effect was blocked by the \u00b5 and \u03b4-opioid receptor antagonists, naloxonazine (10 mg\/kg, intraperitoneally) and naltrindole (3 mg\/kg, intraperitoneally), and it was potentiated by a \u03ba-opioid receptor antagonist, norbinaltrophimine (1 mg\/kg, subcutaneously ). Combined treatment with subeffective doses of m-trifluoromethyl-diphenyl diselenide (10 mg\/kg, intragastric) and morphine (1 mg\/kg, subcutaneously) resulted in a synergistic antidepressant-like effect. The opioid system contribution to the m-trifluoromethyl-diphenyl diselenide antidepressant-like action was also demonstrated in the modified tail suspension test, decreasing mouse immobility and swinging time and increasing curling time, results similar to those observed using morphine, a positive control. Treatment with m-trifluoromethyl-diphenyl diselenide induced neither tolerance to the antidepressant-like action nor physical signs of withdrawal, which could be associated with the fact that m-trifluoromethyl-diphenyl diselenide did not change the mouse cortical and hippocampal glutamate uptake and release. m-Trifluoromethyl-diphenyl diselenide treatments altered neither locomotor nor toxicological parameters in mice. These findings demonstrate that m-trifluoromethyl-diphenyl diselenide elicited an antidepressant-like action by direct or indirect \u03bc and \u03b4-opioid receptor activation and the \u03ba-opioid receptor blockade, without inducing tolerance, physical signs of withdrawal and toxicity.<\/jats:p>","DOI":"10.1177\/0269881117724353","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T11:01:23Z","timestamp":1504177283000},"page":"1250-1262","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Opioid system contribution to the antidepressant-like action of\n                    <i>m<\/i>\n                    -trifluoromethyl-diphenyl diselenide in mice: A compound devoid of tolerance and withdrawal syndrome"],"prefix":"10.1177","volume":"31","author":[{"given":"Suzan G","family":"Rosa","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Biologia 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