{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:57:06Z","timestamp":1790873826649,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T00:00:00Z","timestamp":1521590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Brain Health Trust, Otago, NZ.","award":["no specific grant number"],"award-info":[{"award-number":["no specific grant number"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>In this maintenance treatment study, we sought to evaluate the effect on anxiety ratings, safety and tolerability of 3\u2009months of weekly ketamine in 20 patients with treatment-refractory DSM IV generalised anxiety disorder (GAD) and\/or social anxiety disorder (SAD), and subsequent assessment of remission post-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was an uncontrolled open-label study in 20 patients who had been responders in an ascending dose ketamine study. The study was undertaken in a university clinic. Patients received one or two weekly ketamine doses of 1\u2009mg\/kg injected subcutaneously for 3\u2009months. Data were collected from December 2015\u2013June 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There were 10 women (50%) and 10 men (50%); 15 patients (75%) met criteria for GAD and 18 (90%) for SAD. One hour after dosing, Fear Questionnaire ratings decreased by ~50%, as did Hamilton Anxiety ratings. Clinician Administered Dissociative States Scale mean scores declined over time, from 20 points at week\u20091 to 8.8 points at week 14. Compared with pre-dose values, mean systolic and diastolic blood pressure increased by ~10\u2009mm\u2009Hg at 30\u2009min. The most common adverse events were nausea, dizziness and blurred vision. Of the 20 patients, 18 reported improved social functioning and\/or work functioning during maintenance treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Weekly ketamine dosing was safe and well tolerated, and post-dose dissociative symptoms tended to reduce after repeated dosing. Patients reported marked improvements in functionality and in their personal lives. Maintenance ketamine may be a therapeutic alternative for patients with treatment refractory GAD\/SAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>http:\/\/www.anzctr.org.au\/ACTRN12615000617561<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269881118762073","type":"journal-article","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T10:06:42Z","timestamp":1521626802000},"page":"663-667","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":74,"title":["Safety and efficacy of maintenance ketamine treatment in patients with treatment-refractory generalised anxiety and social anxiety disorders"],"prefix":"10.1177","volume":"32","author":[{"given":"Paul","family":"Glue","sequence":"first","affiliation":[{"name":"Department of Psychological Medicine, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shona M","family":"Neehoff","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J","family":"Medlicott","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Kibby","sequence":"additional","affiliation":[{"name":"Southern District Health Board, Dunedin, New 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