{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:28:35Z","timestamp":1777858115240,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["P50DA033945"],"award-info":[{"award-number":["P50DA033945"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21DA033597"],"award-info":[{"award-number":["R21DA033597"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["RL1DA024857"],"award-info":[{"award-number":["RL1DA024857"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32DA007238"],"award-info":[{"award-number":["T32DA007238"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001863"],"award-info":[{"award-number":["UL1TR001863"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Separate \u03b11- and \u03b2-adrenergic antagonists have shown efficacy in reducing nicotine-motivated behaviors in rodents and humans, supporting a role for the noradrenergic system in mediating the reinforcing properties of drugs of abuse. However, the effect of the combined \u03b11- and \u03b2-adrenergic antagonist, carvedilol, on stress-related smoking is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Using a well-established human laboratory model of stress-precipitated smoking-lapse behavior, we examined whether carvedilol (0 or 50 mg\/day; between subject, n=17 per group), administered to steady-state, would attenuate the ability to resist smoking following stress imagery (vs. neutral imagery) and reduce subsequent smoking self-administration in nicotine-deprived smokers ( n = 34 total). Tobacco craving, withdrawal, and physiologic reactivity were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Latency to start smoking and number of cigarettes smoked during the self-administration period did not differ by medication condition. Counter to our hypothesis, tobacco craving demonstrated a medication \u00d7 time effect, with greater craving in the carvedilol condition. Systolic blood pressure and heart rate demonstrated lower values in the carvedilol versus placebo group, consistent with known effects of carvedilol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>While carvedilol attenuated physiologic reactivity consistent with its clinical indication, beneficial effects on smoking outcomes were absent in this preliminary investigation and may suggest possible worsening. Future work may benefit from discerning the single versus combined effects of \u03b11- and \u03b2-adrenergic antagonism on smoking outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269881118767647","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T05:47:38Z","timestamp":1524635258000},"page":"1003-1009","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Pilot investigation of the effect of carvedilol on stress-precipitated smoking-lapse behavior"],"prefix":"10.1177","volume":"32","author":[{"given":"Terril L","family":"Verplaetse","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea H","family":"Weinberger","sequence":"additional","affiliation":[{"name":"Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca L","family":"Ashare","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian P","family":"Pittman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia M","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette M","family":"Tetrault","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meaghan","family":"Lavery","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherry A","family":"McKee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"bibr1-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.5.558"},{"key":"bibr2-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1970-0"},{"key":"bibr3-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.12.001"},{"key":"bibr4-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1080\/14622200020032051"},{"key":"bibr5-0269881118767647","volume-title":"Treating Tobacco Use and Dependence: 2008 Update","author":"Fiore MC","year":"2008"},{"key":"bibr6-0269881118767647","volume-title":"User\u2019s Guide for the Structured Clinical Interview for DSM-IV Axis I Disorders\u2014Research Version","author":"First MB","year":"1996"},{"key":"bibr7-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1559-7"},{"key":"bibr8-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.42"},{"key":"bibr9-0269881118767647","unstructured":"GlaxoSmithKline (2015) Highlights of Prescribing Information: COREG (Carvedilol) Tablets for Oral Use. Available at: https:\/\/www.gsksource.com\/pharma\/content\/dam\/GlaxoSmithKline\/US\/en\/Prescribing_Information\/Coreg\/pdf\/COREG-PI-PIL.PDF (accessed 22 May 2017)."},{"key":"bibr10-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01879.x"},{"key":"bibr11-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1986.01800030107013"},{"key":"bibr12-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2624-6"},{"key":"bibr13-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.06.012"},{"key":"bibr14-0269881118767647","first-page":"343","volume":"22","author":"Levine J","year":"1986","journal-title":"Psychopharmacol Bull"},{"key":"bibr15-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114562091"},{"key":"bibr16-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1177\/0269881110376694"},{"key":"bibr17-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/nts090"},{"key":"bibr18-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1080\/14622200210141257"},{"key":"bibr19-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"bibr20-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12441"},{"key":"bibr21-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1441.030"},{"key":"bibr22-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2008.00134.x"},{"key":"bibr23-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1080\/14622200310001615312"},{"key":"bibr24-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(00)80009-5"},{"key":"bibr25-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e32801155d4"},{"key":"bibr26-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-3896-z"},{"key":"bibr27-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000208"},{"key":"bibr28-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1177\/0269881117699603"},{"key":"bibr29-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-007-0799-7"},{"key":"bibr30-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301263"},{"key":"bibr31-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.3907"},{"key":"bibr32-0269881118767647","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2010.09.013"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881118767647","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0269881118767647","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0269881118767647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:07:49Z","timestamp":1777507669000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0269881118767647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,25]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1177\/0269881118767647"],"URL":"https:\/\/doi.org\/10.1177\/0269881118767647","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,25]]}}}