{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:09:42Z","timestamp":1785434982389,"version":"3.56.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100005205","name":"Janssen Research & Development, LLC","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Seltorexant is a potent and selective antagonist of the orexin-2 receptor that is being developed for the treatment of insomnia and major depressive disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>The primary objective was to investigate the effect of seltorexant on sleep efficiency after single and multiple dose administration in subjects with insomnia disorder without psychiatric comorbidity. Secondary objectives included evaluation of total sleep time, latency to persistent sleep, and wake after sleep onset. Subjects received 40 mg of seltorexant for five days during Period 1 and placebo during Period 2 or vice versa in this randomized, two-way crossover study. Objective sleep parameters were evaluated by polysomnography over 8 h on Day 1\/2 (single dose) and on Day 5\/6 (multiple doses). Subjective sleep parameters were assessed by questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-seven subjects completed the study. The mean changes in sleep efficiency (% (SD)) of seltorexant from placebo at Day 1\/2 were 5.8 (9.2), and 7.9 (9.8) at Day 5\/6 ( p &lt; 0.001 at both time points); in total sleep time (min (SD)) 27.7 (44.3) and 37.9 (47.1), respectively; in latency to persistent sleep (min (SD)) \u221218.8 (21.3) and \u221229.9 (27.7), respectively; and in wake after sleep onset (min (SD)) \u221211.1 (36.4) and \u221211.3 (46.5). The most common adverse events were headache and somnolence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Sleep efficiency was increased with seltorexant treatment compared with placebo. Treatment with seltorexant resulted in a prolonged total sleep time, shorter latency to persistent sleep and wake after sleep onset. There were no unexpected safety findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269881118773745","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T04:03:50Z","timestamp":1527739430000},"page":"668-677","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["A randomized Phase 2 study to evaluate the orexin-2 receptor antagonist seltorexant in individuals with insomnia without psychiatric comorbidity"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3987-7462","authenticated-orcid":false,"given":"Peter","family":"De Boer","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Janssen Research & Development, LLC, Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne C","family":"Drevets","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Janssen Research & Development, LLC, Titusville, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Rofael","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Janssen Research & Development, LLC, Pennington, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6589-455X","authenticated-orcid":false,"given":"Peter","family":"van der Ark","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Janssen Research & Development, LLC, Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine M","family":"Kent","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Psychiatry, Sunovion Pharmaceuticals, Skillman, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Kezic","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Janssen Research & Development, LLC, Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Parapatics","sequence":"additional","affiliation":[{"name":"The Siesta Group, Schlafanalyse GmbH, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Dorffner","sequence":"additional","affiliation":[{"name":"The Siesta Group, Schlafanalyse GmbH, Vienna, Austria"},{"name":"The Medical University of Vienna, Center for Medical Statistics, Informatics and Intelligent Systems, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joop","family":"van Gerven","sequence":"additional","affiliation":[{"name":"Center for Human Drug Research, Leiden University Medical Center, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Bene\u0161","sequence":"additional","affiliation":[{"name":"Department of Early Development, Neuroscience, Somni Bene GmbH, Schwerin and Rostock University Medical Center, Schwerin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Keicher","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, Charit\u00e9 Research Organization GmbH, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Jahn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Seiden","sequence":"additional","affiliation":[{"name":"Baptist Sleep Center, Hollywood, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy","family":"Luthringer","sequence":"additional","affiliation":[{"name":"Minerva Neurosciences, Waltham, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,5,31]]},"reference":[{"key":"bibr1-0269881118773745","doi-asserted-by":"publisher","DOI":"10.3109\/00207459008994241"},{"key":"bibr2-0269881118773745","doi-asserted-by":"publisher","DOI":"10.1159\/000320864"},{"key":"bibr3-0269881118773745","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.225466"},{"key":"bibr4-0269881118773745","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1974.tb02285.x"},{"key":"bibr5-0269881118773745","doi-asserted-by":"publisher","DOI":"10.2533\/chimia.2008.974"},{"key":"bibr6-0269881118773745","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.9.1155"},{"key":"bibr7-0269881118773745","unstructured":"Cogstate (2015) Cogstate Brief Battery. 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