{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:13:15Z","timestamp":1793862795664,"version":"4.6.1"},"reference-count":58,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["SC2GM109811"],"award-info":[{"award-number":["SC2GM109811"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Preclinical evidence from male subjects indicates that exposure to psychotropic medications, during early development, results in long-lasting altered responses to reward-related stimuli. However, it is not known if exposure to the antidepressant fluoxetine, in female subjects specifically, changes sensitivity to natural and drug rewards, later in life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>The aim of this work was to investigate if exposure to fluoxetine mediates enduring changes in sensitivity to the rewarding properties of cocaine and sucrose, using female mice as a model system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We exposed C57BL\/6 female mice to fluoxetine (250 mg\/L in their drinking water) for 15 consecutive days, either during adolescence (postnatal day 35\u201349) or adulthood (postnatal day 70\u201384). Twenty-one days later, mice were examined on their behavioral reactivity to cocaine (0, 2.5, 5, 7.5 mg\/kg) using the conditioned place preference paradigm, or assessed on the two-bottle sucrose (1%) test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We found that regardless of age of antidepressant exposure, female mice pre-exposed to fluoxetine displayed reliable conditioning to the cocaine-paired compartment. However, when compared to respective age-matched controls, antidepressant pre-exposure decreased the magnitude of conditioning at the 5 and 7.5 mg\/kg cocaine doses. Furthermore, fluoxetine pre-exposure reduced sucrose preference without altering total liquid intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The data suggest that pre-exposure to fluoxetine, during adolescence or adulthood, results in a prolonged decrease in sensitivity to the rewarding properties of both natural and drug rewards in female C57BL\/6 mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269881118805488","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T11:16:39Z","timestamp":1539861399000},"page":"145-153","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Fluoxetine exposure in adolescent and adult female mice decreases cocaine and sucrose preference later in life"],"prefix":"10.1177","volume":"33","author":[{"given":"Francisco J","family":"Flores-Ramirez","sequence":"first","affiliation":[{"name":"Department of Psychology, The University of Texas at El Paso, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Garcia-Carachure","sequence":"additional","affiliation":[{"name":"Department of Psychology, The University of Texas at El Paso, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Psychology, The University of Texas at El Paso, El Paso, TX, USA"},{"name":"Department of Psychology, California State University, San Bernardino, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celene","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Psychology, California State University, San Bernardino, CA, 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