{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:20:57Z","timestamp":1788880857946,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2014 SGR 680"],"award-info":[{"award-number":["2014 SGR 680"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["SGR 2014\/1125"],"award-info":[{"award-number":["SGR 2014\/1125"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Impulse post-doctoral Marie Curie"},{"DOI":"10.13039\/501100000897","name":"Directorate-General for Justice","doi-asserted-by":"publisher","award":["HOME\/2014\/JDRU\/AG\/DRUG\/7082"],"award-info":[{"award-number":["HOME\/2014\/JDRU\/AG\/DRUG\/7082"]}],"id":[{"id":"10.13039\/501100000897","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Severo Ochoa"},{"name":"Spanish Health National System","award":["CPII16\/00027"],"award-info":[{"award-number":["CPII16\/00027"]}]},{"name":"Red de Trastornos Adictivos","award":["RTA RD12\/0028\/0006"],"award-info":[{"award-number":["RTA RD12\/0028\/0006"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The unprecedented proliferation of new psychoactive substances (NPS) threatens public health and challenges drug policy. Information on NPS pharmacology and toxicity is, in most cases, unavailable or very limited and, given the large number of new compounds released on the market each year, their timely evaluation by current standards is certainly challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>We present here a metabolomics-targeted approach to predict the pharmacological profile of NPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We have created a machine learning algorithm employing the quantification of monoamine neurotransmitters and steroid hormones in rats to predict the similarity of new drugs to classical ones of abuse (MDMA (3,4-methyl\u2009enedioxy\u2009methamphetamine), methamphetamine, cocaine, heroin and \u0394\n                      <jats:sup>9<\/jats:sup>\n                      -tetrahydrocannabinol).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We have characterized each classical drug of abuse and two examples of NPS (mephedrone and JWH-018) following alterations observed in the targeted metabolome profile (monoamine neurotransmitters and steroid hormones) in different brain areas, plasma and urine at 1\u2004h and 4\u2004h post drug\/vehicle administration. As proof of concept, our model successfully predicted the pharmacological profile of a synthetic cannabinoid (JWH-018) as a cannabinoid-like drug and synthetic cathinone (mephedrone) as a MDMA-like psychostimulant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our approach allows a fast NPS pharmacological classification which will benefit both drug risk evaluation policies and public health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269881118812103","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T08:35:13Z","timestamp":1542616513000},"page":"347-354","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Metabolomics predicts the pharmacological profile of new psychoactive substances"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8677-9964","authenticated-orcid":false,"given":"Eul\u00e0lia","family":"Olesti","sequence":"first","affiliation":[{"name":"Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain"},{"name":"Department of Experimental and Health Sciences, Pompeu Fabra University (CEXS-UPF), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilario","family":"De Toma","sequence":"additional","affiliation":[{"name":"Department of Experimental and Health Sciences, Pompeu Fabra University (CEXS-UPF), Barcelona, Spain"},{"name":"Cellular & Systems Neurobiology, Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes G","family":"Ramaekers","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor M","family":"Brunt","sequence":"additional","affiliation":[{"name":"Amsterdam Institute for Addiction Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Department of Drug Monitoring & Policy, Netherlands Institute of Mental Health and Addiction (Trimbos Institute), Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel\u00b7l\u00ed","family":"Carb\u00f3","sequence":"additional","affiliation":[{"name":"Department of Experimental and Health Sciences, Pompeu Fabra University (CEXS-UPF), Barcelona, Spain"},{"name":"Biomedical Research, Prous Institute, Barcelona, Spain"},{"name":"Department of Pharmacology, Toxicology and Therapeutic Chemistry. Faculty of Pharmacy and Food Sciences, University of Barcelona. Av. Joan XXIII 27-31, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Fern\u00e1ndez-Avil\u00e9s","sequence":"additional","affiliation":[{"name":"Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Robledo","sequence":"additional","affiliation":[{"name":"Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain"},{"name":"Department of Experimental and Health Sciences, Pompeu Fabra University (CEXS-UPF), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mag\u00ed","family":"Farr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutic Chemistry. Faculty of Pharmacy and Food Sciences, University of Barcelona. Av. Joan XXIII 27-31, Barcelona, Spain"},{"name":"School of Medicine, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Dierssen","sequence":"additional","affiliation":[{"name":"Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain"},{"name":"Department of Experimental and Health Sciences, Pompeu Fabra University (CEXS-UPF), Barcelona, Spain"},{"name":"Cellular & Systems Neurobiology, Systems Biology Program, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain"},{"name":"School of Medicine, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CB06\/03), CIBEROBN, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d3scar J","family":"Pozo","sequence":"additional","affiliation":[{"name":"Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"de la Torre","sequence":"additional","affiliation":[{"name":"Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain"},{"name":"Department of Experimental and Health Sciences, Pompeu Fabra University (CEXS-UPF), Barcelona, Spain"},{"name":"School of Medicine, Universitat Aut\u00f2noma de Barcelona, Cerdanyola del Vall\u00e8s, Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CB06\/03), CIBEROBN, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,11,19]]},"reference":[{"key":"bibr1-0269881118812103","unstructured":"Anon (2010) European Comission, Press Release Database. 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