{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:21:49Z","timestamp":1780579309566,"version":"3.54.1"},"reference-count":56,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"SENY Fundaci\u00f3","award":["CI 2005\u20130308007"],"award-info":[{"award-number":["CI 2005\u20130308007"]}]},{"name":"Instituto de Investigacion Sanitaria Valdecilla","award":["Next-Val 2017 (NVAL 17\/24)"],"award-info":[{"award-number":["Next-Val 2017 (NVAL 17\/24)"]}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Servicios Sociales e Igualdad","doi-asserted-by":"publisher","award":["Plan Nacional de Drogas Research Grant 2005. Orden"],"award-info":[{"award-number":["Plan Nacional de Drogas Research Grant 2005. Orden"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI020499, PI050427, and PI060507."],"award-info":[{"award-number":["PI020499, PI050427, and PI060507."]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cannabis smoking is highly prevalent among patients with psychotic disorders. Its use has been found to be related to clinical characteristics and the prognosis of the disorder. Recent evidence indicates a protective effect of cannabis on weight gain and related metabolic alterations. However, there are no previous studies on the long-term longitudinal effects of cannabis on first-episode drug-na\u00efve patients, which would thereby avoid the confounding effects of chronicity and previous treatment exposure. We aimed to explore the effect of cannabis smoking on weight and lipid\/glycaemic metabolic measures in a sample of first-episode non-affective psychosis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>Anthropometric measurements and glycaemic and lipid parameters were obtained at baseline and three years after initiation of treatment. Patients self-reported their cannabis use at both time points. To explore the longitudinal effect of cannabis, patients were divided into three groups: continuers, discontinuers and non-users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Cannabis users at baseline presented a lower weight ( F=14.85, p&lt;0.001), body mass index ( F=13.14, p&lt;0.001), total cholesterol ( F=4.85, p=0.028) and low-density lipoprotein-cholesterol ( F=6.26, p=0.013) compared to non-users. These differences were also observed after three years: weight ( F=8.07, p=0.005), body mass index ( F=4.66, p=0.032) and low-density lipoprotein-cholesterol ( F=3.91, p=0.049). Moreover, those patients discontinuing cannabis use presented a higher increase in weight ( F=2.98, p=0.052), body mass index ( F=2.73, p=0.067) and triglyceride-high-density lipoprotein ratio ( F=2.72, p=0.067) than the \u2018non-users\u2019 and \u2018continuers\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The study suggests that cannabis use may produce a protective effect against weight gain and related metabolic alterations in psychosis. However, these results need to be replicated in a larger sample size.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269881118822173","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T15:49:02Z","timestamp":1548949742000},"page":"284-294","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Effect of cannabis on weight and metabolism in first-episode non-affective psychosis: Results from a three-year longitudinal study"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5478-3376","authenticated-orcid":false,"given":"Javier","family":"V\u00e1zquez-Bourgon","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University Hospital Marqu\u00e9s de Valdecilla-Instituto Investigaci\u00f3n Sanitaria Valdecilla (IDIVAL), Santander, Spain"},{"name":"Department of Medicine and Psychiatry, University of Cantabria, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Seti\u00e9n-Suero","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University Hospital Marqu\u00e9s de Valdecilla-Instituto Investigaci\u00f3n Sanitaria Valdecilla (IDIVAL), Santander, Spain"},{"name":"Department of Medicine and Psychiatry, University of Cantabria, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuencisla","family":"Pilar-Cu\u00e9llar","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Santander, Spain"},{"name":"Department of Physiology and Pharmacology, University of Cantabria, Santander, Spain"},{"name":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, University of Cantabria-Consejo Superior de Investigaciones Cient\u00edficas (CSIC)-Sociedad para el Desarrollo de Cantabria (SODERCAN), Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Romero-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University Hospital Marqu\u00e9s de Valdecilla-Instituto Investigaci\u00f3n Sanitaria Valdecilla (IDIVAL), Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Ortiz-Garc\u00eda de la Foz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University Hospital Marqu\u00e9s de Valdecilla-Instituto Investigaci\u00f3n Sanitaria Valdecilla (IDIVAL), Santander, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Castro","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Santander, Spain"},{"name":"Department of Physiology and Pharmacology, University of Cantabria, Santander, Spain"},{"name":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, University of Cantabria-Consejo Superior de Investigaciones Cient\u00edficas (CSIC)-Sociedad para el Desarrollo de Cantabria (SODERCAN), Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicto","family":"Crespo-Facorro","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University Hospital Marqu\u00e9s de Valdecilla-Instituto Investigaci\u00f3n Sanitaria Valdecilla (IDIVAL), Santander, Spain"},{"name":"Department of Medicine and Psychiatry, University of Cantabria, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,31]]},"reference":[{"key":"bibr1-0269881118822173","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"bibr2-0269881118822173","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000314"},{"key":"bibr3-0269881118822173","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000990"},{"key":"bibr4-0269881118822173","unstructured":"American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, 4th Edition. 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