{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:30:20Z","timestamp":1777858220836,"version":"3.51.4"},"reference-count":70,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004382","name":"polska akademia nauk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004382","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ERA-NET Neuron II JTC"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      Like other psychedelics, D-lysergic acid diethylamide (LSD) affects numerous serotonin receptors, and according to the current dogma, the 5-HT\n                      <jats:sub>2A<\/jats:sub>\n                      receptors are considered the main target for its hallucinogenic effects. LSD, however, also displays agonistic activity at the 5-HT\n                      <jats:sub>5A<\/jats:sub>\n                      receptors, which mediate some of LSD-induced behavioural effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Using male Sprague Dawley rats, we examined the effects of 5-HT\n                      <jats:sub>2A<\/jats:sub>\n                      and 5-HT\n                      <jats:sub>5A<\/jats:sub>\n                      receptor antagonists on LSD-induced stimulus control in the two-lever drug discrimination test using a FR10 schedule of reinforcement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In animals trained to discriminate 0.08 mg\/kg LSD from vehicle 15 minutes after injection, LSD produced dose-related increases in response, with an ED50 (\u00b195% confidence limits) of 0.0384 (\u00b1 0.025\u20130.051) mg\/kg). LSD-like responses were observed when the training dose of LSD was given 5\u201330 but not 90 minutes before the test. Confirming earlier reports, the 5-HT antagonist ketanserin (2 mg\/kg) attenuated the LSD response in 50% of rats, and due to pretreatment with 0.2 and 2 mg\/kg MDL 100907, 63% and 67% of animals, respectively, failed to select the LSD lever. We then investigated the effects of two 5-HT\n                      <jats:sub>5A<\/jats:sub>\n                      receptor antagonists, and we found that 56% and 60% of rats pretreated with 3 and 10 mg\/kg SB 699551, respectively, failed to select the LSD lever. Due to pretreatment with 0.01 mg\/kg ASP 5736, 58% of rats did not select the LSD lever. This dose also reduced the response rate but not the number of rats failing to complete the test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      The present results suggest that antagonists of the 5-HT\n                      <jats:sub>5A<\/jats:sub>\n                      receptor may inhibit subjective effects of LSD in rats.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269881119867603","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T07:58:04Z","timestamp":1566892684000},"page":"1447-1455","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Serotonin type 5A receptor antagonists inhibit D-lysergic acid diethylamide discriminatory cue in 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