{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:36:55Z","timestamp":1787996215320,"version":"build-2784847793"},"reference-count":52,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Investissements d\u2019Avenir program","award":["ANR-11-IDEX-0004-02"],"award-info":[{"award-number":["ANR-11-IDEX-0004-02"]}]},{"name":"Commissariat \u00e0 l\u2019\u00e9nergie atomique et aux \u00e9nergies alternatives"},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FDM20151234954"],"award-info":[{"award-number":["FDM20151234954"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018375","name":"Fondation FondaMental","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018375","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011272","name":"FP7 Health","doi-asserted-by":"publisher","award":["HEALTH-F2-2010-242114"],"award-info":[{"award-number":["HEALTH-F2-2010-242114"]}],"id":[{"id":"10.13039\/100011272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Antipsychotic-induced weight gain is a common and debilitating side effect of antipsychotics. Although genome-wide association studies of antipsychotic-induced weight gain have been performed, few genome-wide loci have been discovered. Moreover, these genome-wide association studies have included a wide variety of antipsychotic compounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>We aim to gain more insight in the genomic loci affecting antipsychotic-induced weight gain. Given the variable pharmacological properties of antipsychotics, we hypothesized that targeting a single antipsychotic compound would provide new clues about genomic loci affecting antipsychotic-induced weight gain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All subjects included for this genome-wide association study ( n=339) were first-episode schizophrenia spectrum disorder patients treated with amisulpride and were minimally medicated (defined as antipsychotic use &lt;2\u2009weeks in the previous year and\/or &lt;6\u2009weeks lifetime). Weight gain was defined as the increase in body mass index from before until approximately 1 month after amisulpride treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Our genome-wide association analyses for antipsychotic-induced weight gain yielded one genome-wide significant hit (rs78310016; \u03b2=1.05; p=3.66 \u00d7 10\n                      <jats:sup>\u221208<\/jats:sup>\n                      ; n=206) in a locus not previously associated with antipsychotic-induced weight gain or body mass index. Minor allele carriers had an odds ratio of 3.98 ( p=1.0 \u00d7 10\n                      <jats:sup>\u221203<\/jats:sup>\n                      ) for clinically meaningful antipsychotic-induced weight gain (\u2a7e7% of baseline weight). In silico analysis elucidated a chromatin interaction with 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1. In an attempt to replicate single-nucleotide polymorphisms previously associated with antipsychotic-induced weight gain, we found none were associated with amisulpride-induced weight gain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our findings suggest the involvement of rs78310016 and possibly 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 in antipsychotic-induced weight gain. In line with the unique binding profile of this atypical antipsychotic, our findings furthermore hint that biological mechanisms underlying amisulpride-induced weight gain differ from antipsychotic-induced weight gain by other atypical antipsychotics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269881120907972","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T04:15:51Z","timestamp":1583295351000},"page":"524-531","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["A new genetic locus for antipsychotic-induced weight gain: A genome-wide study of first-episode psychosis patients using amisulpride (from the OPTiMiSE cohort)"],"prefix":"10.1177","volume":"34","author":[{"given":"Sophie E","family":"ter Hark","sequence":"first","affiliation":[{"name":"Department of Translational Neuroscience, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4321-4100","authenticated-orcid":false,"given":"St\u00e9phane","family":"Jamain","sequence":"additional","affiliation":[{"name":"Psychiatrie Translationnelle, Inserm U955, Cr\u00e9teil, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Est, Cr\u00e9teil, France"},{"name":"Fondation FondaMental, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Schijven","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bochao D","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Boland-Auge","sequence":"additional","affiliation":[{"name":"Centre National de Recherche en G\u00e9nomique Humaine, Institut de Biologie Fran\u00e7ois Jacob, Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Deleuze","sequence":"additional","affiliation":[{"name":"Centre National de Recherche en G\u00e9nomique Humaine, Institut de Biologie Fran\u00e7ois Jacob, Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9jane","family":"Troudet","sequence":"additional","affiliation":[{"name":"Psychiatrie Translationnelle, Inserm U955, Cr\u00e9teil, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Est, Cr\u00e9teil, France"},{"name":"Fondation FondaMental, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K","family":"Malhotra","sequence":"additional","affiliation":[{"name":"The Zucker School of Medicine at Hofstra\/Northwell, Hempstead, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"G\u00fcl\u00f6ks\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology, School for Mental Health Neuroscience Maastricht University Medical Center, Maastricht, The Netherlands"},{"name":"Department of Psychiatry, Yale School of Medicine, New Haven, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiaan H","family":"Vinkers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Amsterdam UMC (location VUmc), Amsterdam, The Netherlands"},{"name":"Department of Anatomy and Neurosciences, Amsterdam UMC (location VUmc), Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn H","family":"Ebdrup","sequence":"additional","affiliation":[{"name":"Centre for Neuropsychiatric Schizophrenia Research, Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Glostrup, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 S","family":"Kahn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands"},{"name":"Department of Psychiatry, Icahn School of Medicine, Mount Sinai, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Leboyer","sequence":"additional","affiliation":[{"name":"Psychiatrie Translationnelle, Inserm U955, Cr\u00e9teil, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Est, 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