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We demonstrated that neonatal hypoxia-ischemia (HI) induced attentional deficits in rats and MPH administration reversed these deficits. However, MPH effects on memory deficits after the HI procedure have not been evaluated yet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>We aimed to analyze learning and memory performance of young hypoxic-ischemic rats after MPH administration and associate their performance with brain-derived neurotrophic factor (BDNF) levels in the prefrontal cortex and hippocampus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Male Wistar rats were divided into four groups ( n=11\u201313\/group): control saline (CTS), control MPH (CTMPH), HI saline (HIS) and HIMPH. The HI procedure was conducted at post-natal day (PND) 7 and memory tasks between PND 30 and 45. MPH administration (2.5\u2009mg\/kg, i.p.) occurred 30\u2009min prior to each behavioral session and daily, for 15\u2009days, for the BDNF assay ( n=5\u20137\/group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>As expected, hypoxic-ischemic animals demonstrated learning and memory deficits in the novel-object recognition (NOR) and Morris water maze (MWM) tasks. However, MPH treatment did not improve learning and memory deficits of these animals in the MWM\u2014and even disrupted the animals\u2019 performance in the NOR task. Increased BDNF levels were found in the hippocampus of HIMPH animals, which seem to have been insufficient to improve memory deficits observed in this group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The MPH treatment was not able to improve memory deficits resulting from the HI procedure considering a dose of 2.5\u2009mg\/kg. Further studies investigating different MPH doses would be necessary to determine a dose\u2013response relationship in this model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269881120913153","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T17:36:13Z","timestamp":1586280973000},"page":"750-758","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Methylphenidate treatment increases hippocampal BDNF levels but does not improve memory deficits in hypoxic-ischemic rats"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7427-0159","authenticated-orcid":false,"given":"Patr\u00edcia Maidana","family":"Miguel","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neuroci\u00eancias, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade (ICBS), Universidade Federal do Rio Grande do Sul, Porto 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