{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:18:50Z","timestamp":1784330330366,"version":"3.55.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T00:00:00Z","timestamp":1592006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100012215","name":"Newman Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012215","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["RO1 AG026569-01."],"award-info":[{"award-number":["RO1 AG026569-01."]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006416","name":"bone and joint injury prevention and rehabilitation center, university of michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale:<\/jats:title>\n                    <jats:p>Benzodiazepines are useful and commonly prescribed. Unfortunately, they are associated with subtle but functionally significant neurocognitive side effects that increase the risk of motor vehicle accidents and falls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this study was to determine whether clinically feasible measures of simple reaction time and reaction accuracy are sensitive to a single dose of lorazepam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Using a randomized, double-blind, crossover design, 26 healthy adults (13 women; age = 26.9 \u00b1 8.2\u2009yr) were given 1.0\u2009mg lorazepam or placebo 90\u2009minutes prior to two data collection sessions. Participants completed simple and reaction accuracy tasks using a standardized \u201cruler drop\u201d testing paradigm during each session. Outcomes were mean and variability of simple reaction time and reaction accuracy, which evaluates a participant\u2019s ability to catch the device solely on the random 50% of trials that lights affixed to it illuminate on release. Reaction accuracy requires a go\/no-go decision within 420\u2009ms before the falling device strikes the floor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>As compared with placebo, lorazepam increased simple reaction time variability (range = 43 \u00b1 18 vs. 60 \u00b1 23\u2009ms, respectively; p = 0.004 and standard deviation = 14.6 \u00b1 5.7 vs. 19.7 \u00b1 7.3\u2009ms, respectively; = 0.006) and decreased reaction accuracy (90 \u00b1 7% vs. 84 \u00b1 11%, respectively; p = 0.010).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Given prior work demonstrating associations between simple reaction time and reaction accuracy and functional outcomes such as self-protection, response to perturbations, and fall risk, these clinically available measures may have a role in identifying subtle, functionally significant cognitive changes related to short-term benzodiazepine use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269881120915409","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T04:45:15Z","timestamp":1592023515000},"page":"920-925","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["A clinical method of evaluating simple reaction time and reaction accuracy is sensitive to a single dose of lorazepam"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9426-196X","authenticated-orcid":false,"given":"James K","family":"Richardson","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T","family":"Eckner","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hogene","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A","family":"Ashton-Miller","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,13]]},"reference":[{"key":"bibr1-0269881120915409","unstructured":"AAAS Science NetLinks (2019) Science Fact: Tennis Serves. 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