{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:33:13Z","timestamp":1793403193771,"version":"4.5.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Psychedelic drugs have shown an efficacy in some psychiatric disorders and have an original mechanism of action with a 5-HT\n                      <jats:sub>2A<\/jats:sub>\n                      agonism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim of this meta-analysis was to assess by a quantitative analysis the putative efficacy of psychedelic drugs on depressive symptoms and to investigate the kinetic of this efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We searched the MEDLINE and PsycINFO databases through April 2019, without limits on year of publication. Means and standard deviations were extracted to calculate standardized mean differences (SMD). Scores of depressive symptoms were compared with baseline scores at days 7, 14, and 21; weeks 4\u20135 and 6\u20138; and months 3 and 6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eight studies were included in this meta-analysis. A significant decrease of depressive symptoms was found from day 1 ( n\u2009=\u20095 studies; SMD\u2009=\u2009\u20121.4, 95% confidence interval (CI): \u20122.33 to \u20120.48, p\u2009=\u20090.003) to 6\u2009months ( n\u2009=\u20094 studies; SMD\u2009=\u2009\u20121.07, 95% CI: \u20121.44 to \u20120.7, p\u2009&lt;\u20090.001) after psychedelic sessions. No serious adverse effect was reported in all included studies. A transient increase of the heart rate, blood systolic, and diastolic pressure were found after psychedelics compared with placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This meta-analysis shows that psychedelic treatments were safe and could contribute to a rapid improvement of depressive symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269881120919957","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T03:16:21Z","timestamp":1590376581000},"page":"1079-1085","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":105,"title":["Efficacy of psychedelic treatments on depressive symptoms: A meta-analysis"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3699-2024","authenticated-orcid":false,"given":"Bruno","family":"Romeo","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Addictology, APHP, Paul Brousse Hospital, Villejuif, France"},{"name":"Faculte de Medecine, Paris Sud University, Le Kremlin-Bicetre, \u00cele-de-France, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Paris, France"},{"name":"Unit\u00e9 Psychiatrie-Comorbidit\u00e9s-Addictions-Unit\u00e9 de Recherche PSYCOMADD 4872; Universit\u00e9 Paris-Sud-APHP, Universit\u00e9 Paris Saclay, Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Karila","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Addictology, APHP, Paul Brousse Hospital, Villejuif, France"},{"name":"Faculte de Medecine, Paris Sud University, Le Kremlin-Bicetre, \u00cele-de-France, France"},{"name":"Unit\u00e9 Psychiatrie-Comorbidit\u00e9s-Addictions-Unit\u00e9 de Recherche PSYCOMADD 4872; Universit\u00e9 Paris-Sud-APHP, Universit\u00e9 Paris Saclay, Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Martelli","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Addictology, APHP, Paul Brousse Hospital, Villejuif, France"},{"name":"Faculte de Medecine, Paris Sud University, Le Kremlin-Bicetre, \u00cele-de-France, France"},{"name":"Unit\u00e9 Psychiatrie-Comorbidit\u00e9s-Addictions-Unit\u00e9 de Recherche PSYCOMADD 4872; Universit\u00e9 Paris-Sud-APHP, Universit\u00e9 Paris Saclay, Villejuif France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Research unit, NeuroImaging and Psychiatry, Paris Sud University-Paris Saclay University, Paris Descartes University, Digiteo Labs, Gif-sur- Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amine","family":"Benyamina","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Addictology, APHP, Paul Brousse Hospital, Villejuif, France"},{"name":"Faculte de Medecine, Paris Sud University, Le Kremlin-Bicetre, \u00cele-de-France, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Paris, France"},{"name":"Unit\u00e9 Psychiatrie-Comorbidit\u00e9s-Addictions-Unit\u00e9 de Recherche PSYCOMADD 4872; Universit\u00e9 Paris-Sud-APHP, Universit\u00e9 Paris Saclay, Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,25]]},"reference":[{"key":"bibr1-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114565144"},{"key":"bibr2-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2017.04.007"},{"key":"bibr3-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-014-1486-4"},{"key":"bibr4-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4771-x"},{"key":"bibr5-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30065-7"},{"key":"bibr6-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119598109"},{"key":"bibr7-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13282-7"},{"key":"bibr8-0269881120919957","doi-asserted-by":"publisher","DOI":"10.3310\/hta7270"},{"key":"bibr9-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1177\/2045125316638008"},{"key":"bibr10-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20426"},{"key":"bibr11-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852918001402"},{"key":"bibr12-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1080\/09540261.2018.1486289"},{"key":"bibr13-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0000000000000113"},{"key":"bibr14-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116675513"},{"key":"bibr15-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.116"},{"key":"bibr16-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.07.016"},{"key":"bibr17-0269881120919957","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions 4.2.6","author":"Higgins JPT","year":"2006"},{"key":"bibr18-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"bibr19-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114548296"},{"key":"bibr20-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"bibr21-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0324-9"},{"key":"bibr22-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.01.046"},{"key":"bibr23-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-012-0321-8"},{"key":"bibr24-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.07.076"},{"key":"bibr25-0269881120919957","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00666"},{"key":"bibr26-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118143"},{"key":"bibr27-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718001356"},{"key":"bibr28-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.10.032"},{"key":"bibr29-0269881120919957","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00974"},{"key":"bibr30-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116675512"},{"key":"bibr31-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.11.1905"},{"key":"bibr32-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.11.036"},{"key":"bibr33-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000436"},{"key":"bibr34-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.04.009"},{"key":"bibr35-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2019.1593559"},{"key":"bibr36-0269881120919957","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(98)00093-8"},{"key":"bibr37-0269881120919957","unstructured":"World Health Organization (n.d.) 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