{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:01:06Z","timestamp":1778792466873,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"UPMC Endowment in Geriatric Psychiatry"},{"DOI":"10.13039\/100013395","name":"taylor family institute for innovative psychiatric research, washington university school of medicine in st. louis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000448"],"award-info":[{"award-number":["UL1 TR000448"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010524","name":"campbell family mental health research institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["P30 MH90333"],"award-info":[{"award-number":["P30 MH90333"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH083643"],"award-info":[{"award-number":["R01 MH083643"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH083648"],"award-info":[{"award-number":["R01 MH083648"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH083660"],"award-info":[{"award-number":["R01 MH083660"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Venlafaxine, a serotonin\u2013norepinephrine reuptake inhibitor, is often used as first- or second-line therapy for depression in older adults. It can be associated with adverse blood pressure (BP) effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Adults \u2a7e60 years of age in a current major depressive episode were treated in a protocolized manner with venlafaxine XR; 429 participants were treated for 8\u201316\u2009weeks with a daily dose up to 300\u2009mg to achieve remission from depression. Cardiac measures included sitting and standing BP and heart rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of participants who were normotensive at baseline, 6.5% were found to have elevated BP during the study (1.9% &lt;225\u2009mg\/day; 9.8% \u2a7e225\u2009mg\/day). There was no significant change in mean BP in the overall sample, or in the subgroup treated with doses \u2a7e225\u2009mg\/day. Additionally, 20.1% of the participants who did not have orthostatic hypotension at baseline were found to have orthostatic hypotension (16.8% &lt;225\u2009mg\/day; 22.4% \u2a7e225\u2009mg\/day). Participants with new-onset orthostatic hypotension were significantly more likely to fall than the other participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A large proportion of older adults treated with venlafaxine experience orthostatic hypotension, putting them at risk for falls. A smaller proportion experience elevated BP. Older patients prescribed venlafaxine, particularly at high doses, should be advised and counseled about these adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269881120944154","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T02:14:38Z","timestamp":1598408078000},"page":"1112-1118","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Hypertension and orthostatic hypotension with venlafaxine treatment in depressed older adults"],"prefix":"10.1177","volume":"34","author":[{"given":"Rafae","family":"Wathra","sequence":"first","affiliation":[{"name":"Campbell Family Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit H","family":"Mulsant","sequence":"additional","affiliation":[{"name":"Campbell Family Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Thomson","sequence":"additional","affiliation":[{"name":"Campbell Family Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle W","family":"Goldberger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Queen\u2019s University, Kingston, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J","family":"Lenze","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine, Saint Louis, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan F","family":"Karp","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine, Pittsburgh, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Sanches","sequence":"additional","affiliation":[{"name":"Campbell Family Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Charles F","family":"Reynolds","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine, Pittsburgh, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-5818","authenticated-orcid":false,"given":"Daniel M","family":"Blumberger","sequence":"additional","affiliation":[{"name":"Campbell Family Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, 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