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Here, we used resting-state functional magnetic resonance imaging to investigate the effects of a single dose of fluoxetine vs. placebo in adolescents with major depressive disorder. In contrast with previous studies in adults that have demonstrated an acute effect of antidepressants on activity within the default mode network, a single dose of fluoxetine did not alter activity in this network in adolescent depression. There were unexpected group activity differences in the motor network, which should be clarified in future research.<\/jats:p>","DOI":"10.1177\/0269881120959608","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T04:07:58Z","timestamp":1604462878000},"page":"1461-1465","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3117-5156","authenticated-orcid":false,"given":"Liliana P","family":"Capit\u00e3o","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Oxford, Oxford, UK"},{"name":"Oxford Health NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Chapman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford, Oxford, UK"},{"name":"Oxford Health NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Filippini","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford, Oxford, UK"},{"name":"Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford, Oxford, UK"},{"name":"Oxford Health NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8995-2099","authenticated-orcid":false,"given":"Susannah E","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford, Oxford, UK"},{"name":"Oxford Health NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"James","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford, Oxford, UK"},{"name":"Oxford Health NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil J","family":"Cowen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford, Oxford, UK"},{"name":"Oxford Health NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine J","family":"Harmer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford, Oxford, UK"},{"name":"Oxford Health NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"bibr1-0269881120959608","doi-asserted-by":"crossref","unstructured":"Capit\u00e3o LP, Chapman R, Murphy SE, et al. (2019) A single dose of fluoxetine reduces neural limbic responses to anger in depressed adolescents. Transl Psychiatry 9: 30. https:\/\/doi.org\/10.1038\/s41398-018-0332-2","DOI":"10.1038\/s41398-018-0332-2"},{"key":"bibr2-0269881120959608","doi-asserted-by":"crossref","unstructured":"Cullen KR, Klimes-Dougan B, Vu DP, et al. (2016) Neural correlates of antidepressant treatment response in adolescents with major depressive disorder. J Child Adolesc Psychopharmacol 26: 705\u2013712. https:\/\/doi.org\/10.1089\/cap.2015.0232","DOI":"10.1089\/cap.2015.0232"},{"key":"bibr3-0269881120959608","doi-asserted-by":"crossref","unstructured":"Filippini N, MacIntosh BJ, Hough MG, et al. (2009) Distinct patterns of brain activity in young carriers of the APOE-4 allele. Proc Natl Acad Sci 106: 7209\u20137214. https:\/\/doi.org\/10.1073\/pnas.0811879106","DOI":"10.1073\/pnas.0811879106"},{"key":"bibr4-0269881120959608","doi-asserted-by":"crossref","unstructured":"Kaufman J, Birmaher B, Brent D, et al. (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36: 980\u2013988. Available at: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9204677 (accessed 3 February 2020).","DOI":"10.1097\/00004583-199707000-00021"},{"key":"bibr5-0269881120959608","doi-asserted-by":"crossref","unstructured":"Loubinoux I, Boulanouar K, Ranjeva JP, et al. (1999) Cerebral functional magnetic resonance imaging activation modulated by a single dose of the monoamine neurotransmission enhancers fluoxetine and fenozolone during hand sensorimotor tasks. J Cereb Blood Flow Metab 19: 1365\u20131375. https:\/\/doi.org\/10.1097\/00004647-199912000-00010","DOI":"10.1097\/00004647-199912000-00010"},{"key":"bibr6-0269881120959608","doi-asserted-by":"crossref","unstructured":"Murphy SE, Norbury R, O\u2019Sullivan U, et al. (2009) Effect of a single dose of citalopram on amygdala response to emotional faces. Br J Psychiatry 194: 535\u2013540. https:\/\/doi.org\/10.1192\/bjp.bp.108.056093","DOI":"10.1192\/bjp.bp.108.056093"},{"key":"bibr7-0269881120959608","doi-asserted-by":"crossref","unstructured":"Posner J, Hellerstein DJ, Gat I, et al. (2013) Antidepressants normalize the default mode network in patients with dysthymia. JAMA Psychiat 70: 373\u2013382. https:\/\/doi.org\/10.1001\/jamapsychiatry.2013.455","DOI":"10.1001\/jamapsychiatry.2013.455"},{"key":"bibr8-0269881120959608","doi-asserted-by":"crossref","unstructured":"Smith SM, Fox PT, Miller KL, et al. (2009) Correspondence of the brain\u2019s functional architecture during activation and rest. 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