{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:30:57Z","timestamp":1777858257886,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"\n Background:<\/jats:title>\n \n Preclinical work revealed significant interactions between ligands of the histamine H\n 3<\/jats:sub>\n receptor and different drugs of abuse. In the case of psychostimulants, the results reported are somewhat controversial and human data are still scarce, despite the fact that an inverse agonist of the H\n 3<\/jats:sub>\n receptor (pitolisant) has reached the market after approval for the treatment of narcolepsy.\n <\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n \n We have studied associations between histamine H\n 3<\/jats:sub>\n receptor gene variants and cocaine use disorder to increase the knowledge of the possible involvement of histamine H\n 3<\/jats:sub>\n receptor in drug abuse.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Seven single nucleotide polymorphisms of the histamine H3 receptor gene were genotyped by using a multiplexing assay in 248 samples of subjects with cocaine use disorder and 500 randomized samples of subjects representative of the Spanish population.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The study of the epidemiological information associated to the samples revealed that subjects with cocaine use disorder broadly abused alcohol, tobacco and cannabinoids. Two single nucleotide polymorphisms (rs3787430 and rs74627870) were found significantly associated with the occurrence of addiction and one more (rs13042865) was specifically related to the severity of cocaine dependence within drug abusers.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n The associations found in this study further extend the hypothesis that histamine H\n 3<\/jats:sub>\n receptor function could be relevant in drug abuse in general and cocaine addiction in particular.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/0269881120961253","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T05:08:19Z","timestamp":1602824899000},"page":"1326-1330","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Histamine H\n 3<\/sub>\n receptor gene variants associated with drug abuse in patients with cocaine use disorder"],"prefix":"10.1177","volume":"34","author":[{"given":"I\u00f1igo","family":"Pallardo-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Facultad de Farmacia and Instituto de Estudio de las Adicciones IEA-CEU, Universidad San Pablo-CEU, Alcorc\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ram\u00f3n","family":"Mu\u00f1oz-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Traslacional, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Gonz\u00e1lez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia and Instituto de Estudio de las Adicciones IEA-CEU, Universidad San Pablo-CEU, Alcorc\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2542-5983","authenticated-orcid":false,"given":"Luis F","family":"Alguacil","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia and Instituto de Estudio de las Adicciones IEA-CEU, Universidad San Pablo-CEU, Alcorc\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"bibr1-0269881120961253","doi-asserted-by":"publisher","DOI":"10.2174\/1568007033482760"},{"key":"bibr2-0269881120961253","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.01.008"},{"key":"bibr3-0269881120961253","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1345-y"},{"key":"bibr4-0269881120961253","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.07.002"},{"key":"bibr5-0269881120961253","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.08.027"},{"key":"bibr6-0269881120961253","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12221"},{"key":"bibr7-0269881120961253","volume-title":"European Drug Report 2019: Trends and Developments","author":"European Monitoring Centre for Drugs and Drug Addiction","year":"2019"},{"key":"bibr8-0269881120961253","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.02.019"},{"key":"bibr9-0269881120961253","unstructured":"Instituto Nacional de Estad\u00edstica (2017) Encuesta Nacional de Salud. 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