{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:12:25Z","timestamp":1783354345103,"version":"3.54.6"},"reference-count":54,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Benzodiazepines have reliable adverse effects on saccadic eye movements, but the impact of sex as a potential modulator of these effects is less clear. A recent study reported stronger adverse effects on the spatial consistency of saccades in females, which may reflect sex differences in cerebellar mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>We aimed to further examine the role of sex as a potential modulator of benzodiazepine effects by employing the saccadic adaptation paradigm, which is known to be sensitive to cerebellar functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of n=50 healthy adults performed a horizontal step prosaccade task and a saccadic adaptation task under 0.5\u2009mg lorazepam, 1\u2009mg lorazepam and placebo in a double-blind, within-subjects design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the prosaccade task, lorazepam had adverse effects on measures of peak velocity, latency and spatial consistency. The administration of 0.5\u2009mg lorazepam led to significant reductions in gain-decrease adaptation, while a dose of 1\u2009mg did not impair adaptation learning. Gain-increase adaptation was generally less pronounced, and unaffected by the drug. There were no significant drug\u00d7sex interactions in either task.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We conclude that a low dose of lorazepam impairs gain-decrease adaptation independent of sex. At higher doses, however, increasing fatigue may facilitate adaptation and thus counteract the adverse effects observed at lower doses. With regards to prosaccades, our findings confirm peak velocity as well as latency and spatial measures as sensitive biomarkers of GABAergic effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0269881120972424","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T05:57:32Z","timestamp":1607061452000},"page":"91-99","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of lorazepam on prosaccades and saccadic adaptation"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-4997","authenticated-orcid":false,"given":"Katharina","family":"Bey","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia V","family":"Lippold","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behrem","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Hurlemann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oldenburg, Bad Zwischenahn, Germany"},{"name":"Research Center Neurosensory Science, University of Oldenburg, Oldenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0160-0281","authenticated-orcid":false,"given":"Ulrich","family":"Ettinger","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"bibr1-0269881120972424","volume-title":"M.I.N.I. 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