{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:31:10Z","timestamp":1777858270534,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Mood disorders are often associated with persistent cognitive impairments. However, pro-cognitive treatments are essentially lacking. This is partially because of poor insight into the neurocircuitry abnormalities underlying these deficits and their change with illness progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>This functional magnetic resonance imaging (fMRI) study investigates the neuronal underpinnings of cognitive impairments and neuronal change after mood episodes in remitted patients with bipolar disorder (BD) using a hippocampus-based picture encoding paradigm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Remitted patients with BD ( n=153) and healthy controls ( n=52) were assessed with neuropsychological tests and underwent fMRI while performing a strategic picture encoding task. A subgroup of patients ( n=43) were rescanned after 16\u2009months. We conducted data-driven hierarchical cluster analysis of patients\u2019 neuropsychological data and compared encoding-related neuronal activity between the resulting neurocognitive subgroups. For patients with follow-up data, effects of mood episodes were assessed by comparing encoding-related neuronal activity change in BD patients with and without episode(s).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Two neurocognitive subgroups were revealed: 91 patients displayed cognitive impairments while 62 patients were cognitively normal. No neuronal activity differences were observed between neurocognitive subgroups within the dorsal cognitive control network or hippocampus. However, exploratory whole-brain analysis revealed lower activity within a small region of middle temporal gyrus in impaired patients, which significantly correlated with poorer neuropsychological performance. No changes were observed in encoding-related neuronal activity or picture recall accuracy with the occurrence of mood episode(s) during the follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Memory encoding fMRI paradigms may not capture the neuronal underpinnings of cognitive impairment or effects of mood episodes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811211008569","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T01:56:43Z","timestamp":1619143003000},"page":"983-991","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Assessment of the neuronal underpinnings of cognitive impairment in bipolar disorder with a picture encoding paradigm and methodological lessons learnt"],"prefix":"10.1177","volume":"35","author":[{"given":"JZ","family":"Petersen","sequence":"first","affiliation":[{"name":"Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Psychology, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-9477","authenticated-orcid":false,"given":"J","family":"Macoveanu","sequence":"additional","affiliation":[{"name":"Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HL","family":"Kj\u00e6rstad","sequence":"additional","affiliation":[{"name":"Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Psychology, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GM","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Neurobiology Research Unit and Center for Experimental Medicine Neuropharmacology, Rigshospitalet, Copenhagen, Denmark"},{"name":"Institute of Clinical Medicine, University of Copenhagen, Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LV","family":"Kessing","sequence":"additional","affiliation":[{"name":"Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"},{"name":"Institute of Clinical Medicine, University of Copenhagen, Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2572-1384","authenticated-orcid":false,"given":"KW","family":"Miskowiak","sequence":"additional","affiliation":[{"name":"Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Psychology, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"bibr1-02698811211008569","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp055"},{"key":"bibr2-02698811211008569","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12133"},{"key":"bibr3-02698811211008569","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291714000439"},{"key":"bibr4-02698811211008569","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2020.107495"},{"key":"bibr5-02698811211008569","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2012.01910.x"},{"key":"bibr6-02698811211008569","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22475"},{"key":"bibr7-02698811211008569","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2019.00180"},{"key":"bibr8-02698811211008569","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"bibr9-02698811211008569","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-17-06690.2003"},{"key":"bibr10-02698811211008569","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.08.018"},{"key":"bibr11-02698811211008569","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2012.06.008"},{"key":"bibr12-02698811211008569","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-015462"},{"key":"bibr13-02698811211008569","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719003738."},{"key":"bibr14-02698811211008569","doi-asserted-by":"crossref","unstructured":"Macoveanu J, Kj\u00e6rstad HL, Vinberg M, et al. (2020) Affective episodes in recently diagnosed patients with bipolar disorder associated with altered working memory-related prefrontal cortex activity: A longitudinal fMRI study. 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