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Controlled laboratory studies with well-defined psychological constructs are valuable to understand how these drugs manifest their therapeutic benefit. However, there are substantial methodological differences between clinical studies investigating therapeutic outcome and laboratory studies investigating the processes that might underlie the therapeutic effects. Here, we examine some of these differences using the example of 3,4-methylenedioxymethamphetamine (MDMA). We review differences in expectancies, social and physical context, participant characteristics, pharmacological factors, and outcome measures in studies with participants who do or do not have psychiatric diagnoses. We describe the challenges and opportunities in translating findings from laboratory studies to the clinic and identify ways to bridge the gap between these approaches.<\/jats:p>","DOI":"10.1177\/02698811211015221","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T09:12:26Z","timestamp":1620119546000},"page":"252-257","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Challenges in translational research: MDMA in the laboratory versus therapeutic settings"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7211-8994","authenticated-orcid":false,"given":"Harriet","family":"de Wit","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anya 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