{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:33:48Z","timestamp":1784000028141,"version":"3.55.0"},"reference-count":109,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.sagepub.com\/licence-information-for-chorus"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["2R01MH074983"],"award-info":[{"award-number":["2R01MH074983"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["5R21DA035493"],"award-info":[{"award-number":["5R21DA035493"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA048012"],"award-info":[{"award-number":["R01DA048012"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32DA024628"],"award-info":[{"award-number":["T32DA024628"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1342962"],"award-info":[{"award-number":["1342962"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cannabis use has been associated with abnormalities in cerebellar mediated motor and non-motor (i.e. cognition and personality) phenomena. Since the cerebellum is a region with high cannabinoid type 1 receptor density, these impairments may reflect alterations of signaling between the cerebellum and other brain regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>We hypothesized that cerebellar-cortical resting-state functional connectivity (rsFC) would be altered in cannabis users, relative to their non-using peers. It was also hypothesized that differences in rsFC would be associated with cannabis use features, such as age of initiation and lifetime use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Cerebellar-cortical and subcortical rsFCs were computed between 28 cerebellar lobules, defined by a spatially unbiased atlas template of the cerebellum, and individual voxels in the cerebral regions, in 41 regular cannabis users (20 female) and healthy non-using peers ( N = 31; 18 female). We also investigated associations between rsFC and cannabis use features (e.g. lifetime cannabis use and age of initiation).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Cannabis users demonstrated hyperconnectivity between the anterior cerebellar regions (i.e. lobule I-IV) with the posterior cingulate cortex, and hypoconnectivity between the rest of the cerebellum (i.e. Crus I and II, lobule VIIb, VIIIa, VIIIb, IX, and X) and the cortex. No associations were observed between features of cannabis use and rsFC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Cannabis use was associated with altered patterns of rsFC from the cerebellum to the cerebral cortex which may have a downstream impact on behavior and cognition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811211019291","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T01:52:28Z","timestamp":1621993948000},"page":"823-832","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Altered cerebellar-cortical resting-state functional connectivity in cannabis users"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0320-3009","authenticated-orcid":false,"given":"Ashley M","family":"Schnakenberg Martin","sequence":"first","affiliation":[{"name":"Department of Psychological and Brain Sciences and Program in Neuroscience, Indiana University, Bloomington, IN, USA"},{"name":"Psychology Service, VA Connecticut Healthcare System, West Haven, CT, USA"},{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6664-0869","authenticated-orcid":false,"given":"Dae-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences and Program in Neuroscience, Indiana University, Bloomington, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5575-8535","authenticated-orcid":false,"given":"Sharlene D","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences and Program in Neuroscience, Indiana University, Bloomington, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences and Program in Neuroscience, Indiana University, Bloomington, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P","family":"Hetrick","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences and Program in Neuroscience, Indiana University, Bloomington, IN, USA"},{"name":"Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Mackie","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences and Program in Neuroscience, Indiana University, Bloomington, IN, USA"},{"name":"Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian F","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"Department of Psychological and Brain Sciences and Program in Neuroscience, Indiana University, Bloomington, IN, USA"},{"name":"Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"bibr1-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1081\/ADA-120015873"},{"key":"bibr2-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2013.00325.x"},{"key":"bibr3-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.01.019"},{"key":"bibr4-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e536"},{"key":"bibr5-02698811211019291","doi-asserted-by":"publisher","DOI":"10.2174\/138161212802884852"},{"key":"bibr6-02698811211019291","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6511a1"},{"key":"bibr7-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.05.027"},{"key":"bibr8-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200003200-00019"},{"key":"bibr9-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2010.04.008"},{"key":"bibr10-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.05.012"},{"key":"bibr11-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070074"},{"key":"bibr12-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0002-7"},{"issue":"3","key":"bibr13-02698811211019291","first-page":"1922","volume":"27","author":"Camchong J","year":"2017","journal-title":"Cerebr Cortex"},{"key":"bibr14-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2014.04.044"},{"key":"bibr15-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2017.07.008"},{"key":"bibr16-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114550354"},{"key":"bibr17-02698811211019291","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2013.00079"},{"key":"bibr18-02698811211019291","volume-title":"IBM SPSS Statistics for Windows. Version 26.0","author":"CORP I","year":"2020"},{"key":"bibr19-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0b013e31820c23fa"},{"key":"bibr20-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300496"},{"key":"bibr21-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.12.059"},{"key":"bibr22-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2010.00261.x"},{"key":"bibr23-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt181"},{"key":"bibr24-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.045"},{"key":"bibr25-02698811211019291","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2012.00080"},{"key":"bibr26-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415297111"},{"key":"bibr27-02698811211019291","volume-title":"Structured Clinical Interview for DSM-IV-TR Axis I Disorders \u2013 Non-patient Edition (SCID-I\/NP, 1\/2010 Revision)","author":"First MB","year":"2002"},{"key":"bibr28-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.077479"},{"key":"bibr29-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.059"},{"key":"bibr30-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2010.07.035"},{"key":"bibr31-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.03.023"},{"key":"bibr32-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00428-9"},{"key":"bibr33-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.05.010"},{"key":"bibr34-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3119"},{"key":"bibr35-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2005.01.028"},{"key":"bibr36-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn059"},{"key":"bibr37-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1037\/a0026269"},{"key":"bibr38-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2005.02.016"},{"key":"bibr39-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.03.059"},{"key":"bibr40-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1776-14.2014"},{"key":"bibr41-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.39"},{"key":"bibr42-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.1858"},{"key":"bibr43-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1159\/000327318"},{"key":"bibr44-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.04.001"},{"key":"bibr45-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.12.006"},{"key":"bibr46-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90413-8"},{"key":"bibr47-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2006.02.006"},{"key":"bibr48-02698811211019291","volume-title":"Monitoring the Future National Results on Adolescent Drug Use: Overview of Key Findings, 2011","author":"Johnston L","year":"2012"},{"key":"bibr49-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.07.051"},{"key":"bibr50-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.110"},{"key":"bibr51-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-011-0321-y"},{"key":"bibr52-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2011.01.006"},{"key":"bibr53-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxr017"},{"key":"bibr54-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00721.x"},{"key":"bibr55-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00375-8"},{"key":"bibr56-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(02)00069-0"},{"key":"bibr57-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706415"},{"key":"bibr58-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2015.1037947"},{"key":"bibr59-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1111\/j.1556-4029.2010.01441.x"},{"key":"bibr60-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(99)00040-5"},{"key":"bibr61-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.11.005"},{"key":"bibr62-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00935-9"},{"key":"bibr63-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.12.028"},{"key":"bibr64-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12101"},{"key":"bibr65-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6709-10.2011"},{"key":"bibr66-02698811211019291","volume-title":"Marijuana: The Greatest Cause of Illegal Drug Abuse","author":"ONDCP","year":"2008"},{"key":"bibr67-02698811211019291","doi-asserted-by":"publisher","DOI":"10.3109\/00952990.2013.848213"},{"key":"bibr68-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsr.2018.03.006"},{"key":"bibr69-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"bibr70-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.048"},{"key":"bibr71-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.12.008"},{"key":"bibr72-02698811211019291","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00054"},{"key":"bibr73-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2003.10.008"},{"key":"bibr74-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.03.015"},{"key":"bibr75-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1111\/add.13347"},{"key":"bibr76-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20554"},{"key":"bibr77-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyv092"},{"key":"bibr78-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0080"},{"key":"bibr79-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.04.019"},{"key":"bibr80-02698811211019291","volume-title":"Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings","author":"SAMHSA","year":"2011"},{"key":"bibr81-02698811211019291","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1975.36.117"},{"key":"bibr82-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2915-6"},{"key":"bibr83-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.01.011"},{"key":"bibr84-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevNeurobiol.v15.i2.10"},{"key":"bibr85-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.65"},{"key":"bibr86-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301506"},{"key":"bibr87-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.14.4.422"},{"key":"bibr88-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2008.04.016"},{"key":"bibr89-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2004.00806.x"},{"key":"bibr90-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs188"},{"key":"bibr91-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2556-1"},{"key":"bibr92-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.08.039"},{"key":"bibr93-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.065"},{"key":"bibr94-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.31.060407.125606"},{"key":"bibr95-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00436-3"},{"key":"bibr96-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000377"},{"key":"bibr97-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711000526"},{"key":"bibr98-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.280"},{"key":"bibr99-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4927(91)90030-T"},{"key":"bibr100-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4927(96)02817-X"},{"key":"bibr101-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.01.002"},{"key":"bibr102-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1038\/nature21726"},{"key":"bibr103-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1177\/0269881119841568"},{"key":"bibr104-02698811211019291","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666160822151323"},{"key":"bibr105-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.05.046"},{"key":"bibr106-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1300\/J069v19n01_01"},{"key":"bibr107-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06422.x"},{"key":"bibr108-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-018-9782-9"},{"key":"bibr109-02698811211019291","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4803-6"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811211019291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02698811211019291","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811211019291","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811211019291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:10:34Z","timestamp":1777507834000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02698811211019291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,25]]},"references-count":109,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1177\/02698811211019291"],"URL":"https:\/\/doi.org\/10.1177\/02698811211019291","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,25]]}}}