{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:15:14Z","timestamp":1788995714977,"version":"build-2803163510"},"reference-count":96,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a drug-induced hypersensitivity reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>Aim was to review reports of clozapine-related reactions fulfilling the registry of severe cutaneous adverse reaction (RegiSCAR) criteria for DRESS syndrome reported as such or otherwise, to provide a descriptive overview of demographic patterns, clinical manifestations, and DRESS course and investigate associations between demographic, DRESS parameters, and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This review was conducted following preferred reporting items for systematic reviews and meta-analyses guidelines and registered with PROSPERO (registration number CRD42020156385). We searched PubMed\/Embase\/PsychInfo\/Cochrane for reports of clozapine-related reactions meeting RegiSCAR criteria. Associations between RegiSCAR scores and time-to-recovery with demographic\/clinical variables were assessed. Demographic\/clinical characteristics of patients with versus without reported DRESS were compared using non-parametrical tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We identified 26 reports of 27 patients meeting RegiSCAR criteria. Males (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200919, 70.4%) and patients with schizophrenia (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200918, 66.7%) were mainly affected. Twelve patients (44.4%) received clozapine-monotherapy. DRESS symptoms manifested within a month after clozapine initiation (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200924, 88.9%). Lungs and liver were the most common organs involved (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200912, 44.4%;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200911, 40.7%), with a mean time to recovery of 33.75\u2009days. Clozapine rechallenge led to DRESS recurrence in four patients. Death rate was 7.4%. No associations were detected between RegiSCAR criteria or days to recovery with any demographic\/clinical variables. No differences between patients with versus without reported DRESS were detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Clozapine-related DRESS may be rare, but also underreported. Clinicians need to be aware of it even in patients under clozapine-monotherapy or without skin rash.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811211021587","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T16:09:09Z","timestamp":1622304549000},"page":"1062-1073","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Unravelling cases of clozapine-related Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in patients reported otherwise: A systematic review"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6928-1224","authenticated-orcid":false,"given":"Renato","family":"de Filippis","sequence":"first","affiliation":[{"name":"Department of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA"},{"name":"Psychiatry Unit, Department of Health Sciences, University Magna 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