{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:52:22Z","timestamp":1791809542565,"version":"4.3.4"},"reference-count":67,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Schizophrenia is known to be accompanied with increased cardiovascular mortality, which causes reduced life expectancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim of the current study was to investigate if atherogenic index of plasma (AIP) could be a good marker in assessing cardiovascular disease (CVD) risk in patients with schizophrenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients with schizophrenia ( n\u2009=\u2009328) and healthy controls ( n\u2009=\u2009141) were recruited. Schizophrenia patients were evaluated according to the presence of antipsychotic (AP) drug use as AP(+)Sch group and AP(\u2212)Sch group. Atherogenic indices, such as AIP, Castelli\u2019s risk index-I (CRI-I), Castelli\u2019s risk index-II (CRI-II), and atherogenic coefficient (AC), were calculated according to the laboratory examination of serum lipid parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>According to the comparison of serum lipid levels, triglyceride (TG) levels were found to be highest and high-density lipoprotein\u2013cholesterol levels were lowest in AP(+)Sch group than AP(\u2212)Sch group and control group (CG) ( p\u2009&lt;\u20090.001). AIP, CRI-I, and CRI-II scores were found to be significantly higher in AP(+)Sch group than AP(\u2212)Sch group, and in AP(\u2212)Sch than healthy controls ( p\u2009&lt;\u20090.001). Mean AC scores were higher in AP(+)Sch group than both AP(\u2212)Sch and CG and were similar in AP(\u2212)Sch and control subjects ( p\u2009&lt;\u20090.001). According to the correlation analysis, AIP scores were positively correlated with duration of disease ( r\u2009=\u20090.235; p\u2009=\u20090.002) and age ( r\u2009=\u20090.226; p\u2009=\u20090.003) in AP(+)Sch group but not in drug-free subjects. In all groups, atherogenic indices of CRI-I, CRI-II, and AC scores were found to be positively correlated with AIP scores ( p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our results suggest that AIP is an easily calculable and reliable marker for determining the CVD risk in both drug-free schizophrenia patients and patients under AP treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811211026450","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T07:06:00Z","timestamp":1624691160000},"page":"1120-1126","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Evidence for the atherogenic index of plasma as a potential biomarker for cardiovascular disease in 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