{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:11:06Z","timestamp":1791076266246,"version":"4.1.0"},"reference-count":85,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["4108\u201300004B"],"award-info":[{"award-number":["4108\u201300004B"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["6110-00518B"],"award-info":[{"award-number":["6110-00518B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005111","name":"Rigshospitalet","doi-asserted-by":"publisher","award":["R130-A5324"],"award-info":[{"award-number":["R130-A5324"]}],"id":[{"id":"10.13039\/501100005111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R231-2016-3236"],"award-info":[{"award-number":["R231-2016-3236"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["746850"],"award-info":[{"award-number":["746850"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Psilocybin is a psychedelic drug that has shown lasting positive effects on clinical symptoms and self-reported well-being following a single dose. There has been little research into the long-term effects of psilocybin on brain connectivity in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Evaluate changes in resting-state functional connectivity (RSFC) at 1\u2009week and 3\u2009months after one psilocybin dose in 10 healthy psychedelic-na\u00efve volunteers and explore associations between change in RSFC and related measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Participants received 0.2\u20130.3\u2009mg\/kg psilocybin in a controlled setting. Participants completed resting-state functional magnetic resonance imaging (fMRI) scans at baseline, 1-week and 3-month post-administration and [11C]Cimbi-36 PET scans at baseline and 1\u2009week. We examined changes in within-network, between-network and region-to-region RSFC. We explored associations between changes in RSFC and psilocybin-induced phenomenology as well as changes in psychological measures and neocortex serotonin 2A receptor binding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Psilocybin was well tolerated and produced positive changes in well-being. At 1\u2009week only, executive control network (ECN) RSFC was significantly decreased (Cohen\u2019s\n                      <jats:italic toggle=\"yes\">d<\/jats:italic>\n                      \u2009=\u2009\u22121.73, pFWE\u2009=\u20090.010). We observed no other significant changes in RSFC at 1\u2009week or 3\u2009months, nor changes in region-to-region RSFC. Exploratory analyses indicated that decreased ECN RSFC at 1\u2009week predicted increased mindfulness at 3\u2009months (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009\u22120.65).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These findings in a small cohort indicate that psilocybin affects ECN function within the psychedelic \u2018afterglow\u2019 period. Our findings implicate ECN modulation as mediating psilocybin-induced, long-lasting increases in mindfulness. Although our findings implicate a neural pathway mediating lasting psilocybin effects, it is notable that changes in neuroimaging measures at 3\u2009months, when personality changes are observed, remain to be identified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811211026454","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T05:21:41Z","timestamp":1625030501000},"page":"74-84","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":73,"title":["Lasting effects of a single psilocybin dose on resting-state functional connectivity in healthy individuals"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6360-5224","authenticated-orcid":false,"given":"Drummond E-Wen","family":"McCulloch","sequence":"first","affiliation":[{"name":"Neurobiology Research Unit and NeuroPharm, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Korsbak","family":"Madsen","sequence":"additional","affiliation":[{"name":"Neurobiology Research Unit and NeuroPharm, Rigshospitalet, Copenhagen, Denmark"},{"name":"Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-4637","authenticated-orcid":false,"given":"Dea Siggaard","family":"Stenb\u00e6k","sequence":"additional","affiliation":[{"name":"Neurobiology Research Unit and NeuroPharm, Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Psychology, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"Neurobiology Research Unit and NeuroPharm, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Ozenne","sequence":"additional","affiliation":[{"name":"Neurobiology Research Unit and NeuroPharm, Rigshospitalet, Copenhagen, Denmark"},{"name":"Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Steen","family":"Jensen","sequence":"additional","affiliation":[{"name":"Neurobiology Research Unit and NeuroPharm, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte Moos","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Neurobiology Research Unit and NeuroPharm, Rigshospitalet, Copenhagen, Denmark"},{"name":"Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8115-0611","authenticated-orcid":false,"given":"Patrick MacDonald","family":"Fisher","sequence":"additional","affiliation":[{"name":"Neurobiology Research Unit and NeuroPharm, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100538."},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59282-y."},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881115609019."},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.042."},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114565144."},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.84.4.822."},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsaa044."},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.118.017160."},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4771-x"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119598109."},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715002901."},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13282-7."},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12419."},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.4135\/9781849200479.n9."},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.3285."},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-73216-8."},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12904."},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.68."},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.02.001."},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0015808."},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.035."},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2012.00786.x."},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881119845793."},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0000000000000113."},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2004.04.002."},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116675513."},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2358-5."},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0457-5."},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199602000-00004."},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1640-6."},{"key":"e_1_3_3_32_1","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm S","year":"1979","unstructured":"Holm S (1979) A simple sequentially rejective multiple test procedure. Scand J Stat 6: 65\u201370.","journal-title":"Scand J Stat"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00180-012-0344-y."},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsy002."},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600493."},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1037\/pas0000196."},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/00952990.2016.1170135."},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108093587."},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0071."},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22833."},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3263."},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00315."},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881111420188."},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0324-9."},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2020.02.001."},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114568040."},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-0718-8."},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n1110."},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-00906-2."},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-019-05445-3."},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.011478."},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00132."},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-011-0083-5."},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881118780612."},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00269."},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0017816000027577."},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881120909409."},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-372560-8.X5000-1."},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2016_459."},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.12.027."},{"key":"e_1_3_3_61_1","unstructured":"R Studio Team (2020) R Studio. Available at: http:\/\/www.rstudio.com\/"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2011.0019."},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0172."},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00204."},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx036."},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx179."},{"key":"e_1_3_3_67_1","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan DV","year":"1998","unstructured":"Sheehan DV, Lecrubier Y, Sheehan KH, et al. (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59: 22\u201333.","journal-title":"J Clin Psychiatry"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24870."},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2015.12.2.227."},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.081."},{"key":"e_1_3_3_71_1","article-title":"Dokumentation for den danske udgave af NEO PI-R og NEO PI-R Kort Version","author":"Skovdahl-Hansen H","year":"2004","unstructured":"Skovdahl-Hansen H, Mortensen EL, Scioetz H (2004) Dokumentation for den danske udgave af NEO PI-R og NEO PI-R Kort Version. Copenhagen, Denmark: Dansk Psykologisk Forlag.","journal-title":"Psykologisk Forlag"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcbs.2019.11.002."},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.04.009."},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0028727."},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25138."},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881120959609."},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18809547."},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012412."},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.117."},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.10.017."},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.02.010."},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199812010-00024."},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-032511-143049."},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073."},{"key":"e_1_3_3_85_1","doi-asserted-by":"crossref","unstructured":"Wickham H (2016) ggplot2: Elegant Graphics for Data Analysis. New York: Springer-Verlag. Available at: https:\/\/ggplot2.tidyverse.org\/","DOI":"10.1007\/978-3-319-24277-4_9"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00782."}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811211026454","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02698811211026454","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811211026454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:10:35Z","timestamp":1777507835000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02698811211026454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":85,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1177\/02698811211026454"],"URL":"https:\/\/doi.org\/10.1177\/02698811211026454","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.01.28.428377","asserted-by":"object"}]},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]}}}