{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:31:15Z","timestamp":1777858275251,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fonds d\u2019enseignement et de recherche de la Facult\u00e9 de pharmacie de l\u2019Universit\u00e9 Laval"},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Janssen and Otsuka-Lundbeck Alliance"},{"name":"Otsuka-Lundbeck Alliance, Janssen, Sunovion, and Mylan"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Clozapine has a unique efficacy profile among individuals suffering from treatment-resistant schizophrenia, but is associated with hematological side effects. The use of granulocyte colony-stimulating factors (G-CSF) to allow clozapine continuation or rechallenge has emerged as a promising option, but evidence is still scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To describe the largest case series so far published regarding this practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>\n                      A national clozapine hematological monitoring database was consulted to identify all patients who had had neutrophil count &lt;1.5\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L since 2004 in Quebec and was cross-referenced with hospital pharmacy software to identify patients who had received at least one dose of G-CSF, such as filgrastim, while being exposed to clozapine. All data were collected retrospectively, using patients\u2019 medical files, from January to July 2019.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Using G-CSF, three out of eight patients could maintain clozapine despite neutropenia episodes that otherwise would have required treatment discontinuation. The only side effect reported was mild short-lived back pain, over a mean 3-year follow-up period. In all but one case, filgrastim was used on an \u201cas-needed\u201d basis at doses of 300\u2009mcg administered subcutaneously.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These results suggest that the \u201cas-needed\u201d use of G-CSF is well-tolerated and may allow clozapine rechallenge in some well-selected patients, adding to the paucity of data regarding long-term safety and efficacy of this strategy. More research may help to better define potential candidates and optimal regimen of such practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811211029737","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T01:31:51Z","timestamp":1625621511000},"page":"1152-1157","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Clozapine rechallenge following neutropenia using granulocyte colony-stimulating factor: A Quebec case series"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6697-1799","authenticated-orcid":false,"given":"Laurent","family":"B\u00e9chard","sequence":"first","affiliation":[{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Institut universitaire en sant\u00e9 mentale de Qu\u00e9bec, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de la 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Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc-Andr\u00e9","family":"Thivierge","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 Laval, Qu\u00e9bec, Canada"},{"name":"Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de l\u2019Estrie \u2013 Centre hospitalier universitaire de Sherbrooke, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles-\u00c9mile","family":"Lafreni\u00e8re","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de pharmacie, Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc-Andr\u00e9","family":"Roy","sequence":"additional","affiliation":[{"name":"Institut universitaire en sant\u00e9 mentale de Qu\u00e9bec, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de la Capitale-Nationale, Quebec, Canada"},{"name":"D\u00e9partement de psychiatrie et 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