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Chemotherapy-related cognitive deficits (CRCDs) occur in cancer patients, and these deficits persist following treatment, adversely impacting quality of life. To date, there are no approved treatments for this condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Because +Ch improves impaired memory, it was of interest to determine whether +Ch can attenuate spatial memory deficits induced by the chemotherapeutic agents doxorubicin (DOX) and cyclophosphamide (CYP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Female BALB\/C mice, 64\u2009days of age, were trained in the Morris water maze and baseline performance determined on day 15. Following baseline assessment, mice were placed on +Ch diet (2.0% Ch) or remained on standard diet (0.12% Ch). Mice received intravenous injections of DOX (2.5\u2009mg\/kg) and CYP (25\u2009mg\/kg), or equivalent volumes of saline (0.9% NaCl), on days 16, 23, 30, and 37, and spatial memory was assessed weekly from day 22 to 71.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>DOX and CYP produced a prolonged impairment in spatial memory as indicated by an increased latency to the correct zone ( p\u2009&lt;\u20090.05), and a decrease in time in the correct zone ( p\u2009&lt;\u20090.05), % of total swim distance in the correct zone ( p\u2009&lt;\u20090.05) and % entries to the correct zone ( p\u2009&lt;\u20090.05). These effects were attenuated by +Ch.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although it remains to be determined whether this effect extends to other cognitive domains and whether +Ch is prophylactic or therapeutic, these findings suggest that +Ch may be an effective intervention for CRCDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811211029752","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T01:23:52Z","timestamp":1625534632000},"page":"1300-1309","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Increasing dietary choline attenuates spatial memory deficits resulting from exposure to the chemotherapeutic agents cyclophosphamide and doxorubicin"],"prefix":"10.1177","volume":"35","author":[{"given":"Bethany 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