{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:01Z","timestamp":1787018761482,"version":"build-2736575974"},"reference-count":52,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University of Toronto Department of Psychiatry Excellence Funds","award":["2016\/17"],"award-info":[{"award-number":["2016\/17"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Benzodiazepine treatment recommendations for older adults differ markedly between guidelines, especially their advice on the acceptability of long-term use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>Using population-based data we compared risks associated with chronic versus intermittent benzodiazepine usage in older adults. The primary outcome was falls resulting in hospital\/emergency department visits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We undertook a retrospective population-based cohort study using linked healthcare databases in adults aged\u2009\u2a7e\u200966\u2009years in Ontario, Canada, with a first prescription for benzodiazepines. Chronic and intermittent benzodiazepine users, based on the 180\u2009days from index prescription, were matched (1:2 ratio) by sex, age and propensity score, then followed for up to 360\u2009days. Hazard ratios (HRs) for outcomes were calculated from Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 57,041 chronic and 113,839 matched intermittent users were included. Hospitalization\/emergency department visits for falls occurred during follow up in 4.6% chronic versus 3.2% intermittent users (HR\u2009=\u20091.13, 95% confidence interval (CI): 1.08 to 1.19; p\u2009&lt;\u20090.0001). There were significant excess risks in chronic users for most secondary outcomes: hip fractures, hospitalizations\/emergency department visits, long-term care admission and death, but not wrist fractures. Adjustment for benzodiazepine dosage had minimal impact on HRs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study demonstrates evidence of significant excess risks associated with chronic benzodiazepine use compared to intermittent use. The excess risks may inform decision-making by older adults and clinicians about whether short- or long-term benzodiazepine use is a reasonable option for symptom management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811211069096","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T07:02:42Z","timestamp":1643698962000},"page":"460-469","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Comparative safety of chronic versus intermittent benzodiazepine prescribing in older adults: A population-based cohort study"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0095-5993","authenticated-orcid":false,"given":"Simon JC","family":"Davies","sequence":"first","affiliation":[{"name":"Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada"},{"name":"Department of Psychiatry, University of 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