{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:12Z","timestamp":1788566412579,"version":"build-2803163510"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005205","name":"Janssen Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Intranasal esketamine demonstrates rapid improvement of depressive symptoms. However, transient adverse effects (dissociation, sedation and dizziness) may occur, which could impact driving performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To evaluate the effects of 84\u2009mg intranasal esketamine on driving performance in unipolar major depressive disorder (MDD) or persistent depressive disorder (PDD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study consisted of two parts. Part A was a single-blind, double-dummy, randomized three-period, cross-over study to compare effects of esketamine versus placebo on next morning driving, 18\u2009\u00b1\u20092\u2009h post-treatment. Alcohol was administered to demonstrate assay sensitivity. In Part B, same-day driving, 6\u2009\u00b1\u20090.5\u2009hours post-treatment, was assessed during twice weekly esketamine administration for 3\u2009weeks. Twenty-seven patients with mild-to-moderate MDD or PDD without psychotic features completed a 100\u2009km on-the-road driving test on a public highway in normal traffic. The primary outcome was standard deviation of lateral position (SDLP; cm; weaving of car).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In Part A, alcohol impaired driving performance compared to placebo: Least-square means (95% CI), p-value for delta SDLP (cm) compared with placebo: (\u0394SDLP\u2009=\u2009+\u20091.83 (1.03; 2.62), p\u2009&lt;\u20090.001), whereas esketamine did not: (\u0394SDLP\u2009=\u2009\u22120.23 (\u22121.04; 0.58), p\u2009=\u20090.572). In Part B, weekly driving tests showed no differences between placebo baseline SDLP and after esketamine administration over 3\u2009weeks: Day 11: (\u0394SDLP\u2009=\u2009\u22120.96 (\u22123.72; 1.81), p\u2009=\u20090.493), Day 18: (\u0394SDLP\u2009=\u2009\u22120.56 (\u22123.33; 2.20), p\u2009=\u20090.686) and Day 25: (\u0394SDLP\u2009=\u2009\u22121.05 (\u22123.82; 1.71), p\u2009=\u20090.451).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this study, esketamine did not impair on-road driving performance the next morning following a single dose, or on same day after repeated administration.<\/jats:p>\n                  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