{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:07:51Z","timestamp":1784214471409,"version":"3.55.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Benzodiazepines, Z-drugs, pregabalin, and melatonin (BZPMs) have been associated with a higher risk of traffic accidents, but the evidence is inconsistent, and lacking for newer drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To examine the association of BZPMs with risk of traffic accidents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All Danish adults ( n\u2009=\u20093,823,588) were followed for redeemed prescriptions of BZPM and for incident traffic accidents registered in Danish registers from 2002 through 2018. Associations were examined in cohort and case-crossover designs using Cox proportional hazard and conditional logistic regression with adjustment for co-variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 19.3% ( n\u2009=\u2009738,019) of all participants initiated treatment with BZPMs. During the mean follow-up of 10.3\u2009years, 595,173(15.5%) of participants were involved in a traffic accident. In the cohort analysis, all BZPMs besides pregabalin were associated with a higher risk of traffic accidents in adults below 70\u2009years, with chlordiazepoxide showing the strongest association (hazard ratio (HR)\n                      <jats:sub>age 18\u201349<\/jats:sub>\n                      \u2009=\u20091.76, 95% confidence interval (CI): 1.67\u20131.86 and HR\n                      <jats:sub>age 50\u201369<\/jats:sub>\n                      \u2009=\u20091.84, 95% CI: 1.70\u20132.00). In the older age groups, the specific BZPM medications were associated with lower or no risk of traffic accidents. However, in case\u2013time-crossover analysis with inherited control for confounders, no BZPM medication was positively associated with traffic accidents, except for chlordiazepoxide, which had a higher odds ratio in middle-aged group (1.62, 95% CI: 1.15\u20132.29).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study does not fully support that BZPM use is a risk factor for traffic accidents. However, a positive association was found for chlordiazepoxide, which is approved for treatment of acute alcohol withdrawal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811221080465","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T08:58:01Z","timestamp":1651222681000},"page":"470-478","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of benzodiazepines, Z-drugs, pregabalin, and melatonin with traffic accidents: A nationwide cohort and case-crossover study in Danish adults"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-220X","authenticated-orcid":false,"given":"Merete","family":"Osler","sequence":"first","affiliation":[{"name":"Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospitals, Frederiksberg, Denmark"},{"name":"Section for Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1321-8901","authenticated-orcid":false,"given":"Martin B","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Psychiatric Centre Copenhagen, Department of Psychiatry, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"bibr1-02698811221080465","unstructured":"Analyser om benzodiazepiner\u2014Sundhedsdatastyrelsen (n.d.). 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