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However, whether the regular naturalistic use of psychedelics can be linked to more persistent trait-level changes in these domains remains an open question.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To test the hypotheses that (1) using psychedelics is related to higher positive and lower negative emotional reactivity; and (2) an adaptive pattern of self-consciousness, including diminished public self-consciousness and rumination, and increased reflection and self-awareness; and (3) these relations are mediated by the intensity of past ego-dissolution and mystical experiences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>An online survey including questions about the history of psychoactive substance use; questionnaires measuring trait levels of emotional reactivity and self-consciousness; questionnaires for retrospective assessment of ego-dissolution and mystical experiences. Data collected from 2516 participants (1661 psychedelics users) were analyzed using robust linear regression and mediation analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A higher number of lifetime uses of psychedelics predicted greater positive and lower negative emotional reactivity; also, in the domain of self-consciousness, it predicted greater reflection and internal state awareness, and reduced rumination tendency and public self-consciousness. Finally, the intensity of past mystical and ego-dissolution experiences mediated almost all the observed relationships between the lifetime number of psychedelics uses and psychological variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Lifetime psychedelics use predicts an adaptive pattern of trait-level emotional reactivity and self-consciousness. Ego-dissolution and mystical experiences are essential in understanding the long-lasting psychological effects of psychedelics use. Our findings might potentially explain previous observations of increased well-being in psychedelics users.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811221089034","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T09:33:21Z","timestamp":1651052001000},"page":"987-1000","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Naturalistic use of psychedelics is related to emotional reactivity and self-consciousness: The mediating role of ego-dissolution and mystical experiences"],"prefix":"10.1177","volume":"36","author":[{"given":"Pawe\u0142","family":"Or\u0142owski","sequence":"first","affiliation":[{"name":"Laboratory of Brain Imaging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Ruban","sequence":"additional","affiliation":[{"name":"Department of Psychology, SWPS University of Social Sciences and Humanities, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5682-5840","authenticated-orcid":false,"given":"Jan","family":"Szczypi\u0144ski","sequence":"additional","affiliation":[{"name":"Laboratory of Brain Imaging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Hobot","sequence":"additional","affiliation":[{"name":"Consciousness Lab, Institute of Psychology & Centre for Brain Research, Jagiellonian University, Krakow, Poland"},{"name":"Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maksymilian","family":"Bielecki","sequence":"additional","affiliation":[{"name":"Department of Psychology, SWPS University of Social Sciences and Humanities, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4609-8029","authenticated-orcid":false,"given":"Micha\u0142","family":"Bola","sequence":"additional","affiliation":[{"name":"Laboratory of Brain Imaging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"bibr1-02698811221089034","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.03.017"},{"key":"bibr2-02698811221089034","doi-asserted-by":"publisher","DOI":"10.1177\/0269881119897615"},{"key":"bibr3-02698811221089034","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6601_11"},{"key":"bibr4-02698811221089034","unstructured":"Andr\u00e9 Q (2021) PyProcessMacro: A python implementation of Andrew F. 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