{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:03:07Z","timestamp":1789495387292,"version":"build-2803163510"},"reference-count":56,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013327","name":"H. Lundbeck A\/S","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013327","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Major depressive disorder (MDD) and generalized anxiety disorder (GAD) are frequently comorbid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To assess the effectiveness of vortioxetine in patients with MDD and comorbid GAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Open-label, 8-week study (NCT04220996) in 100 adult outpatients with severe MDD and severe comorbid GAD receiving vortioxetine as first treatment for the current depressive episode or switching to vortioxetine due to inadequate response to another drug for depression. Vortioxetine starting dosage was 10\u2009mg\/day, with forced up-titration to 20\u2009mg\/day after 1\u2009week. Response was defined as \u2a7e50% decrease in Montgomery\u2013\u00c5sberg Depression Rating Scale (MADRS) and\/or Hamilton Anxiety Rating Scale (HAM-A) total score from baseline; remission defined as MADRS and\/or HAM-A total score \u2a7d10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Clinically meaningful and statistically significant improvements from baseline in symptoms of depression and anxiety, and overall functioning and health-related quality of life, were observed after 8\u2009weeks\u2019 vortioxetine treatment (all changes p\u2009&lt;\u20090.0001 vs baseline). At week 8, rates of MADRS response and remission were 61% and 35%, respectively. Corresponding rates of HAM-A response and remission were 55% and 42%. Response on both the MADRS and HAM-A scales was achieved by 52% of patients; 31% achieved remission on both scales. Vortioxetine dose up-titration was well tolerated; no unexpected adverse events were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Vortioxetine demonstrates effectiveness in significantly reducing symptoms of both depression and anxiety in patients with severe MDD comorbid with severe GAD. Findings support increasing vortioxetine dosage to 20\u2009mg\/day early in the course of therapy, and show that this may be achieved without compromising tolerability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811221090627","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T06:09:51Z","timestamp":1651471791000},"page":"566-577","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Effectiveness of vortioxetine in patients with major depressive disorder comorbid with generalized anxiety disorder: Results of the RECONNECT study"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3605-7223","authenticated-orcid":false,"given":"Michael Cronquist","family":"Christensen","sequence":"first","affiliation":[{"name":"H. Lundbeck A\/S, Valby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Schmidt","sequence":"additional","affiliation":[{"name":"H. Lundbeck A\/S, Valby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iria","family":"Grande","sequence":"additional","affiliation":[{"name":"Bipolar and Depression Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"key":"bibr1-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"bibr2-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.07.015"},{"key":"bibr3-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e3283530ad7"},{"key":"bibr4-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1021\/jm101459g"},{"key":"bibr5-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.12.056"},{"key":"bibr6-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.07.012"},{"key":"bibr7-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.07.045"},{"key":"bibr8-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000018"},{"key":"bibr9-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.07.023"},{"key":"bibr10-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1177\/20451253211013148"},{"key":"bibr11-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1177\/0269881118788826"},{"key":"bibr12-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852921000936."},{"key":"bibr13-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e328303ac5f"},{"key":"bibr14-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2017.02.020"},{"key":"bibr15-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.153"},{"issue":"2","key":"bibr16-02698811221090627","first-page":"321","volume":"29","author":"Endicott J","year":"1993","journal-title":"Psychopharmacology Bulletin"},{"issue":"1","key":"bibr17-02698811221090627","first-page":"29","volume":"22","author":"Endicott J","year":"2007","journal-title":"International Clinical Psychopharmacology"},{"key":"bibr18-02698811221090627","unstructured":"European Medicines Agency (2020) Brintelllix (Vortioxetine): Summary of Product Characteristics. Available at: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/brintellix-epar-product-information_en.pdf"},{"key":"bibr19-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.11.106"},{"key":"bibr20-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1177\/070674371305801205"},{"key":"bibr21-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2019.1546691"},{"key":"bibr22-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.4602"},{"key":"bibr23-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12956"},{"issue":"4","key":"bibr24-02698811221090627","volume":"82","author":"Iovieno N","year":"2021","journal-title":"Journal of Clinical Psychiatry"},{"key":"bibr25-02698811221090627","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14m09335"},{"key":"bibr26-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.10.042"},{"key":"bibr27-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.617"},{"key":"bibr28-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707002012"},{"key":"bibr29-02698811221090627","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10m06191"},{"key":"bibr30-02698811221090627","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10m06176blu"},{"key":"bibr31-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12328"},{"key":"bibr32-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2371"},{"key":"bibr33-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3839-0"},{"key":"bibr34-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000546"},{"key":"bibr35-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.6.651"},{"key":"bibr36-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000259"},{"key":"bibr37-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2424"},{"key":"bibr38-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.189068"},{"key":"bibr39-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(01)00011-5"},{"key":"bibr40-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12565"},{"key":"bibr41-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1002\/da.20583"},{"key":"bibr42-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.6.1171"},{"key":"bibr43-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.04.023"},{"key":"bibr44-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1186\/1745-0179-3-5"},{"key":"bibr45-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.07.011"},{"key":"bibr46-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1002\/da.23113"},{"key":"bibr47-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.07.001"},{"key":"bibr48-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2006.09.008"},{"key":"bibr49-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmy088"},{"key":"bibr50-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852915000334"},{"key":"bibr51-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2850.2011.01735.x"},{"key":"bibr52-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2016.03.007"},{"key":"bibr53-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1017\/S146114571100040X"},{"key":"bibr54-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1177\/0269881115586938"},{"key":"bibr55-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e32832d6bf4"},{"key":"bibr56-02698811221090627","doi-asserted-by":"publisher","DOI":"10.1038\/srep40511"}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811221090627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02698811221090627","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811221090627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:11:00Z","timestamp":1777507860000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02698811221090627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1177\/02698811221090627"],"URL":"https:\/\/doi.org\/10.1177\/02698811221090627","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}