{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:48:38Z","timestamp":1790088518209,"version":"4.0.1"},"reference-count":75,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["219982\/Z\/19\/Z"],"award-info":[{"award-number":["219982\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Abrupt cessation of therapy with a selective serotonin reuptake inhibitor (SSRI) is associated with a discontinuation syndrome, typified by numerous disabling symptoms, including anxiety. Surprisingly, little is known of the behavioural effect of SSRI discontinuation in animals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Here, the effect of SSRI discontinuation on anxiety-like behaviour was systematically investigated in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Experiments were based on a three-arm experimental design comprising saline, continued SSRI and discontinued SSRI. Mice were assessed 2\u2009days after SSRI discontinuation over a 5-day period using the elevated plus maze (EPM) and other anxiety tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>An exploratory experiment found cessation of paroxetine (12\u2009days) was associated with decreased open-arm exploration and reduced total distance travelled, in male but not female mice. Follow-up studies confirmed a discontinuation effect on the EPM in male mice after paroxetine (12\u2009days) and also citalopram (12\u2009days). Mice receiving continued paroxetine (but not citalopram) also showed decreased open-arm exploration but this was dissociable from the effects of discontinuation. The discontinuation response to paroxetine did not strengthen after 28\u2009days of treatment but was absent after 7\u2009days of treatment. A discontinuation response was not discernible in other anxiety and fear-learning tests applied 3\u20135\u2009days after treatment cessation. Finally, discontinuation effects on the EPM were typically associated with decreased locomotion on the test. However, separate locomotor testing implicated anxiety-provoked behavioural inhibition rather than a general reduction in motor activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Overall, this study provides evidence for a short-lasting behavioural discontinuation response to cessation of SSRI treatment in mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811221093032","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T01:55:26Z","timestamp":1653357326000},"page":"794-805","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of selective serotonin reuptake inhibitor discontinuation on anxiety-like behaviours in mice"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4818-5003","authenticated-orcid":false,"given":"Helen M","family":"Collins","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Oxford, Oxford, UK"},{"name":"Department of Experimental Psychology, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Pinacho","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Oxford, Oxford, UK"},{"name":"Department of Experimental Psychology, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dersu","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Bannerman","sequence":"additional","affiliation":[{"name":"Department of 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