{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:16:21Z","timestamp":1793798181833,"version":"4.6.1"},"reference-count":60,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Financing Code 001"],"award-info":[{"award-number":["Financing Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Depression is a psychiatric disorder with limited therapy options. Psychedelics are new antidepressant candidates, being the ayahuasca one of the most promising ones. A synergistic combination of N,N-dimethyltryptamine (DMT) and \u03b2-carbolines allows ayahuasca antidepressant properties. Another psychedelic and DMT-containing beverage is the jurema wine used religiously by indigenous people from Northeastern Brazil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To evaluate the antidepressant-like effect of standardized extract of Mimosa tenuiflora (SEMT), associated or not with harmine (\u03b2-carboline), in behavioral models of depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The SEMT was submitted to (+) ESI-IT-LC\/MS analysis for DMT quantification. To assess the antidepressant-like effect of SEMT, the open field (OFT), tail suspension (TST), and forced swim (FST) tests were performed. To verify the participation of serotonergic systems, the 5-hydroxytryptophan (5-HTP)-induced head twitch test was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The content of DMT found in SEMT was 24.74\u2009\u00b1\u20090.8\u2009mg\/g. Yuremamine was also identified. SEMT presented an antidepressant-like effect in mice submitted to the TST and FST, independent from harmine, with no significant alterations on the OFT. The sub-dose interaction between SEMT and ketamine also produced an anti-immobility effect in the TST, with no changes in the OFT. SEMT potentiated the head twitch behavior induced by 5-HTP and ketanserin prevented its antidepressant-like effect in the TST ( p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      SEMT presented a harmine-independent antidepressant-like effect in mice submitted to the TST and FST. This effect occurs possibly via activation of serotonergic systems, particularly the 5-HT\n                      <jats:sub>2A\/2C<\/jats:sub>\n                      receptors.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811221104050","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T07:13:42Z","timestamp":1655709222000},"page":"836-848","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["\u03b2-carboline-independent antidepressant-like effect of the standardized extract of the barks of\n                    <i>Mimosa tenuiflora<\/i>\n                    (Willd) Poir. occurs via 5-HT\n                    <sub>2A\/2C<\/sub>\n                    receptors in mice"],"prefix":"10.1177","volume":"36","author":[{"given":"Luiz Antonio Miranda de Souza","family":"Duarte-Filho","sequence":"first","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Bioci\u00eancias (PGB) UNIVASF, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Araujo","family":"Amariz","sequence":"additional","affiliation":[{"name":"Rede Nordeste de Biotecnologia (RENORBIO), Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brazil"},{"name":"Central de An\u00e1lise de F\u00e1rmacos, Medicamentos e Alimentos (CAFMA) UNIVASF, Petrolina, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo Hideki Vicente","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Central de An\u00e1lise de F\u00e1rmacos, Medicamentos e Alimentos (CAFMA) UNIVASF, Petrolina, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz Rodrigues","family":"Massaranduba","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade e Biol\u00f3gicas (PGCSB) UNIVASF, Petrolina, Pernambuco, Brazil"},{"name":"Grupo de Pesquisa em Neuroci\u00eancias e Psicologia Experimental (Neurovale) UNIVASF, Petrolina, Pernambuco, Brazil"},{"name":"Grupo de Pesquisa em Processamento de Sinais e Vis\u00e3o Computacional (SigProCV) UNIVASF, Petrolina, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Modesto Nascimento","family":"Menezes","sequence":"additional","affiliation":[{"name":"Rede Nordeste de Biotecnologia (RENORBIO), Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tauana Ara\u00fajo","family":"Damasceno","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Bioci\u00eancias (PGB) UNIVASF, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivani","family":"Brys","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade e Biol\u00f3gicas (PGCSB) UNIVASF, Petrolina, Pernambuco, Brazil"},{"name":"Grupo de Pesquisa em Neuroci\u00eancias e Psicologia Experimental (Neurovale) UNIVASF, Petrolina, Pernambuco, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Ara\u00fajo","family":"Rolim","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Bioci\u00eancias (PGB) UNIVASF, Pernambuco, Brazil"},{"name":"Rede Nordeste de Biotecnologia (RENORBIO), Universidade Federal Rural de Pernambuco, Recife, Pernambuco, Brazil"},{"name":"Central de An\u00e1lise de F\u00e1rmacos, Medicamentos e Alimentos (CAFMA) UNIVASF, Petrolina, Pernambuco, Brazil"},{"name":"Universidade Federal do Vale do S\u00e3o Francisco (UNIVASF), Petrolina, Pernambuco, 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