{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:24:00Z","timestamp":1779207840819,"version":"3.51.4"},"reference-count":82,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In 1967, concerns about the carcinogenic potential of psychedelics arose after chromosomal damage in human leukocytes following in vitro lysergic acid (LSD) exposure was reported in the literature. Worries were further heightened by subsequent reports of leukemia and other cancers in LSD users. Additional investigations of psychedelics\u2019 effects on chromosomes were published over the next decade, with the bulking suggesting these concerns were unfounded. However, the relationship between psychedelics and cancer has been explored only minimally from an epidemiological perspective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To determine whether associations exist between psychedelic use and either lifetime cancer or hematologic cancer diagnoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed data from adult participants in the 2015\u20132019 administrations of the National Survey on Drug Use and Health for associations between lifetime use of psychedelics and lifetime diagnosis of either any cancer or hematologic cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We identified no associations between lifetime psychedelic use and either lifetime cancer diagnosis or hematologic cancer diagnosis. Sub-analyses of lifetime lysergamide, phenethylamine, and tryptamine use also revealed no associations with lifetime cancer or hematologic cancer diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>While laboratory studies and case reports from the 1960s and 1970s generated concerns about psychedelics\u2019 carcinogenic potential, this analysis of recent epidemiological data does not support an association between psychedelic use and development of cancer in general or hematologic cancer. Important study limitations to consider include a lack of information about psychedelic dosage, number of lifetime psychedelic exposures, and the temporal relationship between psychedelic use and cancer diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811221117536","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T05:36:33Z","timestamp":1660628193000},"page":"1118-1128","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Is psychedelic use associated with cancer?: Interrogating a half-century-old claim using contemporary population-level data"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8963-5701","authenticated-orcid":false,"given":"Brian S","family":"Barnett","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychology, Center for Behavioral Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, EC-10 Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, Center for Behavioral Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick","family":"Doblin","sequence":"additional","affiliation":[{"name":"Multidisciplinary Association for Psychedelic Studies, Santa Cruz, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-9644","authenticated-orcid":false,"given":"Andrew D","family":"Carlo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"},{"name":"Meadows Mental Health Policy Institute, Dallas, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.6235"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1972.03200200049011"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.66.3.920"},{"key":"e_1_3_2_5_1","unstructured":"Bronson J Stroop J Zimmer S et al. 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