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A statistical model was developed to distinguish rats expressing or not a cocaine-induced place preference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Two groups of rats were identified: rats that did express rewarding effects (CPP expression (CPPE), score &gt;102\u2009s) and rats that did not (no CPP expression (nCPPE), score between \u221285 and 59\u2009s). These two groups did not show significant differences in a battery of behavioral tests. To identify differentially expressed genes in the CPPE and nCPPE groups, a whole-transcriptome ribonucleic acid-sequencing analysis was performed in the nucleus accumbens (NAc) 24\u2009h after the CPP test. Four immediate early genes (\n                      <jats:italic toggle=\"yes\">Fos<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Egr2<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Nr4a1<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Zbtb37<\/jats:italic>\n                      ) were differentially expressed in the NAc of CPPE rats after expression of CPP. Variability in cocaine-induced place preference persisted in the CPPE and nCPPE groups after the extinction and reinstatement phases. Transcriptomic differences observed after reinstatement were distinct from those observed immediately after expression of CPP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These new findings provide insights into the identification of mechanisms underlying interindividual variability in the response to cocaine\u2019s rewarding effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811221123047","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T06:20:17Z","timestamp":1663568417000},"page":"1161-1175","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Individual differences in cocaine-induced conditioned place preference in male rats: Behavioral and transcriptomic 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