{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:32:20Z","timestamp":1784932340365,"version":"3.55.0"},"reference-count":73,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T00:00:00Z","timestamp":1674259200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The reinforcing properties of nicotine play a critical role in smoking and vaping. There is a need for treatments that decrease the reinforcing properties of nicotine and thereby improve smoking and vaping rates. Dopamine plays a role in the reinforcing properties of nicotine, but little is known about the role of dopamine D2-like receptors in nicotine intake and whether there are sex differences in the effects of dopaminergic drugs on nicotine intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The goal of the present studies was to investigate the effects of the D1\/D2-like receptor antagonist flupentixol and the D2-like receptor antagonist L-741626 on nicotine self-administration in male and female rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The effects of flupentixol and L-741626 on operant responding for nicotine and food and locomotor activity in a small open field were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There were no sex differences in baseline nicotine intake. The D1\/D2-like receptor antagonist flupentixol and the D2-like receptor antagonist L-741626 decreased operant responding for nicotine. Blockade of D1\/D2-like receptors and blockade of D2-like receptors also decreased operant responding for food and decreased locomotor activity. Flupentixol induced a greater decrease in operant responding for food in males than females. However, in the other tests, there were no sex differences in the effects of the dopamine receptor antagonists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Blockade of D1\/D2-like receptors with flupentixol and D2-like receptors with L-741626 decreases nicotine and food intake in rats of both sexes. These compounds also decrease locomotor activity which might be indicative of a sedative effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811221147141","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T05:08:52Z","timestamp":1674277732000},"page":"216-228","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The D1\/D2-like receptor antagonist flupentixol and the D2-like receptor antagonist L-741626 decrease operant responding for nicotine and food and locomotor activity in male and female rats"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2793-022X","authenticated-orcid":false,"given":"Ranjithkumar","family":"Chellian","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azin","family":"Behnood-Rod","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryann","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Wing-Yan King","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-1970","authenticated-orcid":false,"given":"Adriaan W","family":"Bruijnzeel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,21]]},"reference":[{"key":"bibr1-02698811221147141","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.047"},{"key":"bibr2-02698811221147141","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199704140-00034"},{"key":"bibr3-02698811221147141","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.07.007"},{"key":"bibr4-02698811221147141","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2001.tb00207.x"},{"key":"bibr5-02698811221147141","unstructured":"Brenan M (2021) Smoking and Vaping Remain Steady and Low in U.S. Washington, D.C: Gallup. 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