{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:01Z","timestamp":1787018761517,"version":"build-2736575974"},"reference-count":48,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Recreational co-consumption of benzodiazepines and alcohol is a common practise; yet, the cognitive effects of this combination remain poorly understood. This study aimed to investigate the acute cognitive effects of combining a 1\u2009mg dose of alprazolam with a moderate dose of alcohol (target 0.04% blood alcohol concentration (BAC)) in a non-clinical population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this randomised, double-blind, placebo-controlled, crossover trial, participants completed computerised cognitive assessments and the brief biphasic alcohol effects scale (B-BAES) after consuming 1\u2009mg of alprazolam, both with and without a moderate dose of alcohol (target 0.04% BAC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 20 healthy participants (mean age\u2009=\u200928.6, SD\u2009\u00b1\u20094.0\u2009years, 60% female), we found that a peak BAC of 0.03% had no significant impact on cognitive performance. Both the individual use of alprazolam and its combination with alcohol resulted in impaired reaction time, digit vigilance, and verbal, spatial and numeric working memory tasks, although an additive effect when alcohol and alprazolam were consumed together was not evident. The most pronounced cognitive effects occurred at 100\u2009min after dosing, coinciding with increased alprazolam concentrations. Sedative effects were heightened with alcohol, alprazolam and their combination while no stimulative effects were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings highlight the significant implications of a therapeutic dose of alprazolam on impairing cognitive performance. This is particularly relevant considering the frequency of non-medical alprazolam use. Future studies should explore different dosages, administration timings and long-term effects to inform the development of public health policies and guidelines regarding the combined use of alcohol and benzodiazepines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811231200878","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T04:32:22Z","timestamp":1695097942000},"page":"1227-1237","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Acute administration of alprazolam, alcohol and their combination on cognitive performance and mood: A randomised, double-blind, placebo-controlled study"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7607-7344","authenticated-orcid":false,"given":"Blair","family":"Aitken","sequence":"first","affiliation":[{"name":"Centre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4470-4718","authenticated-orcid":false,"given":"Amie C","family":"Hayley","sequence":"additional","affiliation":[{"name":"Centre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia"},{"name":"Institute for Breathing and Sleep, Austin Health, Heidelberg, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talitha C","family":"Ford","sequence":"additional","affiliation":[{"name":"Centre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia"},{"name":"Cognitive Neuroscience Unit, Deakin University, Geelong, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Geier","sequence":"additional","affiliation":[{"name":"Forensic Science SA, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brook A","family":"Shiferaw","sequence":"additional","affiliation":[{"name":"Centre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia"},{"name":"Institute for Breathing and Sleep, Austin Health, Heidelberg, VIC, Australia"},{"name":"Seeing Machines Ltd., Fyshwick, ACT, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke A","family":"Downey","sequence":"additional","affiliation":[{"name":"Centre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC, Australia"},{"name":"Institute for Breathing and Sleep, Austin Health, Heidelberg, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2021.82.553."},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00265843."},{"key":"e_1_3_2_4_1","unstructured":"Australian Institute of Health and Welfare (2022) Alcohol Tobacco and Other Drugs in Australia. Web Report. Available at: https:\/\/www.aihw.gov.au\/reports\/alcohol\/alcohol-tobacco-other-drugs-australia (accessed 13 July 2023)."},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2016.303061."},{"key":"e_1_3_2_6_1","volume-title":"The Alcohol Use Disorders Identification Test","author":"Barbor TF","year":"2001","unstructured":"Barbor TF, Higgins-Biddle JC, Saunders JB, et al (2001) The Alcohol Use Disorders Identification Test. Geneva, Switzerland: World Health Organization."},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2414."},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209239."},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314857."},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2007.00056.x."},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aap.2014.11.001."},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2634."},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acx120."},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/11539050-000000000-00000."},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aap.2021.106052."},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-022-06260-z."},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00637498."},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2015.76.952."},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2017.1296576."},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881119836198."},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R449."},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyab009."},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02284958."},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00437422."},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0669-8."},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04188.x."},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00564901."},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02657051."},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.01.003."},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-222-9_2."},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1974.tb01551.x."},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(00)00067-8."},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01941.x."},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/1064-1297.5.1.28."},{"key":"e_1_3_2_35_1","volume-title":"Physician office visits at which benzodiazepines were prescribed: findings from 2014 to 2016 national ambulatory medical care survey","author":"Santo L","year":"2020","unstructured":"Santo L, Rui P, Ashman JJ (2020) Physician office visits at which benzodiazepines were prescribed: findings from 2014 to 2016 national ambulatory medical care survey. National Health Statistics Reports 137. National Center for Health Statistics, Hyattsville, MD."},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.18203\/2319-2003.ijbcp20205120."},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280132."},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1982.148."},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05823-w."},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2415."},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02246492."},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1979.tb04672.x."},{"key":"e_1_3_2_43_1","volume-title":"National Statement on Ethical Conduct in Human Research 2007 (Updated 2018)","author":"The National Health and Medical Research Council","year":"2018","unstructured":"The National Health and Medical Research Council (2018) National Statement on Ethical Conduct in Human Research 2007 (Updated 2018). Canberra, ACT: Commonwealth of Australia."},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2715."},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244655."},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245243."},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.02.033."},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4659."},{"key":"e_1_3_2_49_1","unstructured":"World Health Organization (2018) Global Status Report on Alcohol and Health 2018. Geneva Switzerland: World Health Organization. Available at: https:\/\/apps.who.int\/iris\/handle\/10665\/274603 (accessed 23 February 2023)."}],"container-title":["Journal of Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811231200878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02698811231200878","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02698811231200878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:11:30Z","timestamp":1777507890000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02698811231200878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,19]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1177\/02698811231200878"],"URL":"https:\/\/doi.org\/10.1177\/02698811231200878","relation":{},"ISSN":["0269-8811","1461-7285"],"issn-type":[{"value":"0269-8811","type":"print"},{"value":"1461-7285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,19]]}}}