{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T06:19:34Z","timestamp":1792995574369,"version":"4.5.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110-2314-B-039-030-MY3"],"award-info":[{"award-number":["MOST 110-2314-B-039-030-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["CMU109-MF-98"],"award-info":[{"award-number":["CMU109-MF-98"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["CMU110-MF-63"],"award-info":[{"award-number":["CMU110-MF-63"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR-111-105"],"award-info":[{"award-number":["DMR-111-105"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW110-TDU-B-212-124004"],"award-info":[{"award-number":["MOHW110-TDU-B-212-124004"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Psychopharmacol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Selective serotonin reuptake inhibitors (SSRIs) have been associated with an increased risk of upper gastrointestinal bleeding (UGIB) in older patients but little is known about the risk associated with individual SSRI drugs and doses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To quantify the risk of UGIB in relation to individual SSRI use in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a nested case\u2013control study within a cohort of 9565 patients aged \u2a7e65\u2009years prescribed SSRIs from 2000 to 2013 using claims data of universal health insurance in Taiwan. Incident cases of UGIB during the follow-up period were identified and matched with three control subjects. Conditional logistic regression was used to estimate the odds ratio (OR) of UGIB associated with individual SSRI use and cumulative dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>UGIB risk increased with the increasing cumulative doses of SSRIs (adjusted OR: 1.28, 95% confidence interval (CI): 1.02\u20131.62 for the highest vs. the lowest tertile). Compared with users of other SSRIs, fluoxetine users were at an increased risk of UGIB (adjusted OR: 1.25, 95% CI: 1.03\u20131.50) with a dose\u2013response manner, whereas paroxetine users had 29% decreased odds (95% CI: 0.56\u20130.91). The increased risk was only observed among current fluoxetine users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Fluoxetine therapy was associated with an increased risk of UGIB in a dose\u2013response manner among older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02698811231218955","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T05:35:46Z","timestamp":1703136946000},"page":"137-144","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Dose of selective serotonin reuptake inhibitors and risk of upper gastrointestinal bleeding in older adults"],"prefix":"10.1177","volume":"38","author":[{"given":"Yu-Hsien","family":"Li","sequence":"first","affiliation":[{"name":"Department of Public Health, China Medical University, Taichung, Taiwan"},{"name":"Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Wen","family":"Hang","sequence":"additional","affiliation":[{"name":"College of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Sleep Medicine Center, Department of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsin","family":"Muo","sequence":"additional","affiliation":[{"name":"Department of Public Health, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Education, China Medical University Hospital, Taichung, Taiwan"},{"name":"Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8713-8816","authenticated-orcid":false,"given":"Pei-Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Public Health, China Medical University, Taichung, Taiwan"},{"name":"National Center for Geriatrics and Welfare Research, National Health Research Institutes, Yunlin, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"bibr1-02698811231218955","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66665-2"},{"key":"bibr2-02698811231218955","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/58.3.M249"},{"key":"bibr3-02698811231218955","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00287-9"},{"key":"bibr4-02698811231218955","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S2468"},{"key":"bibr5-02698811231218955","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002022"},{"key":"bibr6-02698811231218955","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(79)90144-4"},{"key":"bibr7-02698811231218955","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.8.1182"},{"key":"bibr8-02698811231218955","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d4551"},{"key":"bibr9-02698811231218955","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.040"},{"key":"bibr10-02698811231218955","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.08.019"},{"key":"bibr11-02698811231218955","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.1.59"},{"key":"bibr12-02698811231218955","unstructured":"National Health Insurance Research Database, Taiwan. 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